Oxford Index Search Results

You are looking at 1-19 of 19 items for:

sensitive x Clinical Pharmacology and Therapeutics x clear all

sensitive

Overview page. Subjects: Medicine and Health.

adj. possessing the ability to respond to a stimulus. The cells of the retina, for example, are sensitive to the stimulus of light and respond by sending nerve impulses to the...

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Lack of Antidepressant Effects of Low-Voltage-Sensitive T-Type Calcium Channel Blocker Ethosuximide in a Chronic Social Defeat Stress Model: Comparison with (R)-Ketamine

Zheng Tian, Chao Dong, Kai Zhang, Lijia Chang and Kenji Hashimoto.

in International Journal of Neuropsychopharmacology

P ublished online August 2018 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 3298 words.

Abstract

Background

A recent study demonstrated that low-voltage-sensitive T-type calcium channel blocker...

lamotrigine

Overview page. Subjects: Clinical Pharmacology and Therapeutics.

An anticonvulsant phenyltriazine drug, used to treat partial epileptic seizures. Thought to stabilize neuronal membranes by acting on voltage-sensitive sodium channels and thereby...

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goserelin

Overview page. Subjects: Clinical Pharmacology and Therapeutics.

A synthetic decapeptide analogue of luteinizing hormone releasing hormone (LHRH) that acts as a potent inhibitor of pituitary gonadotropin secretion. In males it reduces testosterone levels...

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Subjective Effects

Mitch Earleywine.

in Understanding Marijuana

January 2003; p ublished online April 2010 .

Chapter. Subjects: Clinical Pharmacology and Therapeutics. 8190 words.

Perceptions change during marijuana intoxication. Time and space appear distorted. The senses seem more sensitive. Higher functions like thought, memory and spirituality can alter, too....

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KATP channels and migraine

Inger Jansen-Olesen and Kenneth Beri Ploug.

in Innovative drug development for headache disorders

August 2008; p ublished online May 2013 .

Chapter. Subjects: Neurology; Clinical Pharmacology and Therapeutics. 3959 words.

Chapter 19 discusses Adenosine 5´-triphosphate (ATP) sensitive K+(KATP) channels, and their relation to migraine.

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Myocardial protection with intermittent cross-clamp fibrillation: does preconditioning play a role?

Masahiro Fujii and David J Chambers.

in European Journal of Cardio-Thoracic Surgery

December 2005; p ublished online December 2005 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Cardiovascular Medicine. 7006 words.

Objective: Previously, we showed intermittent cross-clamp fibrillation afforded equivalent protection to cardioplegia. This study examined whether protection induced by...

Nonlinear heart rate variability in CABG patients and the preconditioning effect

Zhong-Kai Wu, Saila Vikman, Jari Laurikka, Erkki Pehkonen, Tiina Iivainen, Heikki V. Huikuri and Matti R. Tarkka.

in European Journal of Cardio-Thoracic Surgery

July 2005; p ublished online July 2005 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Cardiovascular Medicine. 2939 words.

Objective: Heart rate variability (HRV) is the most frequently used noninvasive diagnostic method in the assessment of cardiac autonomic control. The clinical relevance of HRV,...

The treatment of juvenile Huntington’s disease

Martha A. Nance.

in Juvenile Huntington's Disease

January 2009; p ublished online November 2012 .

Chapter. Subjects: Neurology; Clinical Pharmacology and Therapeutics. 5565 words.

Until a medical cure for juvenile Huntington’s disease (JHD) is identified, the optimal management of a child with this condition will require a sensitive team of health professionals...

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Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

Ian M. Copple, Luke M. Shelton, Joanne Walsh, Denise V. Kratschmar, Adam Lister, Alex Odermatt, Christopher E. Goldring, Albena T. Dinkova-Kostova, Tadashi Honda and B. Kevin Park.

in Toxicological Sciences

August 2014; p ublished online August 2014 .

Journal Article. Subjects: Medical Toxicology; Clinical Pharmacology and Therapeutics. 4312 words.

The transcription factor Nrf2 protects against a number of experimental pathologies, and is a promising therapeutic target. The clinical investigation of a potent Nrf2-inducing agent, the...

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Plasma levels and vascular effects of endothelin and big endothelin in patients with stable and unstable angina pectoris undergoing coronary bypass grafting

Ulf Lockowandt, Staffan Bjessmo, Torbjörn Ivert and Anders Franco-Cereceda.

in European Journal of Cardio-Thoracic Surgery

February 2002; p ublished online February 2002 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Cardiovascular Medicine. 3136 words.

Objectives: The aim of this study was to determine the plasma and pericardial levels of endothelin-1 (ET-1) and its precursor big endothelin-1 (Big ET-1) in patients with...

S-Ketamine Rapidly Reverses Synaptic and Vascular Deficits of Hippocampus in Genetic Animal Model of Depression

Maryam Ardalan, Gregers Wegener, Ali H. Rafati and Jens R. Nyengaard.

in International Journal of Neuropsychopharmacology

P ublished online December 2016 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 7012 words.

Abstract

Background:

The neurovascular plasticity of hippocampus is an important theory underlying major...

Morphological and functional evidences of the helical heart from non-invasive cardiac imaging

Francesc Carreras, Manel Ballester, Sandra Pujadas, Ruben Leta and Guillem Pons-Llado.

in European Journal of Cardio-Thoracic Surgery

April 2006; p ublished online April 2006 .

Journal Article. Subjects: Anatomy; Clinical Pharmacology and Therapeutics; Cardiovascular Medicine. 3260 words.

The non-invasive study of cardiac mechanics has been improved after the recent introduction of advanced magnetic resonance and echocardiographic imaging techniques. Tagged and...

Fenfluramine Reduces [11C]Cimbi-36 Binding to the 5-HT2A Receptor in the Nonhuman Primate Brain

Kai-Chun Yang, Vladimir Stepanov, Stefan Martinsson, Anders Ettrup, Akihiro Takano, Gitte M Knudsen, Christer Halldin, Lars Farde and Sjoerd J Finnema.

in International Journal of Neuropsychopharmacology

P ublished online June 2017 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 5922 words.

Abstract

Background

[11C]Cimbi-36 is a serotonin 2A receptor agonist positron emission tomography radioligand that...

Induction of Cannabinoid- and N-Methyl-d-Aspartate Receptor-Mediated Long-Term Depression in the Nucleus Accumbens and Dorsolateral Striatum Is Region and Age Dependent

Xiaoqun Zhang, Ze-Jun Feng and Karima Chergui.

in International Journal of Neuropsychopharmacology

P ublished online January 2015 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 5585 words.

Background:

The adolescent brain is sensitive to experience-dependent plasticity and might be more vulnerable than the adult brain to the effects of some...

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Manganese-Enhanced Magnetic Resonance Imaging Reveals Differential Long-Term Neuroadaptation After Methamphetamine and the Substituted Cathinone 4-Methylmethcathinone (Mephedrone)

Bjørnar den Hollander, Mateusz Dudek, Ilkka Ojanperä, Esko Kankuri, Petri Hyytiä and Esa R Korpi.

in International Journal of Neuropsychopharmacology

April 2015; p ublished online February 2015 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 7305 words.

Background:

In recent years there has been a large increase in the use of substituted cathinones such as mephedrone (4-methylmethcathinone, 4-MMC), a...

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5-HT1A Agonist Properties Contribute to a Robust Response to Vilazodone in the Novelty Suppressed Feeding Paradigm

Alvaro L. Garcia-Garcia, Míriam Navarro-Sobrino, Gila Pilosof, Pradeep Banerjee, Alex Dranovsky and E. David Leonardo.

in International Journal of Neuropsychopharmacology

P ublished online June 2016 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 4190 words.

Background:

Differences in 5-HT1A receptor function have been implicated in vulnerability to depression and in response to treatment. Adding 5-HT1A partial...

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Exposure-Response Relationships during Free-Access Intravenous Alcohol Self-Administration in Nondependent Drinkers: Influence of Alcohol Expectancies and Impulsivity

Bethany L. Stangl, Vatsalya Vatsalya, Molly R. Zametkin, Megan E. Cooke, Martin H. Plawecki, Sean O’Connor and Vijay A. Ramchandani.

in International Journal of Neuropsychopharmacology

P ublished online October 2016 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 6123 words.

Abstract

Background:

Self-administration is a hallmark of all addictive drugs, including alcohol. Human laboratory...

Prefrontal microRNA-221 Mediates Environmental Enrichment-Induced Increase of Locomotor Sensitivity to Nicotine

Adrian M. Gomez, Diego Altomare, Wei-Lun Sun, Narasimha M. Midde, Hao Ji, Michael Shtutman, Jill R. Turner, Kim E. Creek and Jun Zhu.

in International Journal of Neuropsychopharmacology

P ublished online August 2015 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 8090 words.

Background:

Environmental enrichment alters susceptibility in developing drug addiction. We have demonstrated that rats raised in an enriched condition are...

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Dopamine therapy for patients at risk of renal dysfunction following cardiac surgery: science or fiction?

Edwin B.C. Woo, Augustine T.M. Tang, Ahmed El Gamel, Brian Keevil, Donna Greenhalgh, Mark Patrick, Mark T. Jones and Timothy L. Hooper.

in European Journal of Cardio-Thoracic Surgery

July 2002; p ublished online July 2002 .

Journal Article. Subjects: Cardiothoracic Anaesthesia; Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Cardiothoracic Surgery. 3283 words.

Objectives: We aimed to evaluate the renoprotective role of renal-dose dopamine on cardiac surgical patients at high risk of postoperative renal dysfunction. The latter...