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sensitive species

Overview page. Subjects: Environmental Science.

Plant or animal species which are susceptible to changes in habitat or to impacts from human activities.

See overview in Oxford Index

Endothelin signalling regulates volume-sensitive Cl current via NADPH oxidase and mitochondrial reactive oxygen species

Wu Deng, Lia Baki and Clive M. Baumgarten.

in Cardiovascular Research

October 2010; p ublished online May 2010 .

Journal Article. Subjects: Cardiovascular Medicine. 4844 words.

Aims

We assessed regulation of volume-sensitive Cl current (I Cl,swell) by endothelin-1 (ET-1) and characterized the signalling pathway...

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The functions of two species of calcium channel in cardiac muscle excitation-contraction coupling

A.J. Williams.

in European Heart Journal

January 1997; p ublished online January 1997 .

Journal Article. Subjects: Cardiovascular Medicine. 0 words.

The contractile state of cardiac muscle cell is determined by the level of calcium in the cytosol. Each action potential produces a transient elevation of cytosolic calcium. The interaction...

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Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS

Eric Anselm, Marta Chataigneau, Mamadou Ndiaye, Thierry Chataigneau and Valérie B. Schini-Kerth.

in Cardiovascular Research

January 2007; p ublished online January 2007 .

Journal Article. Subjects: Cardiovascular Medicine. 4884 words.

Abstract

Objectives: An enhanced endothelial formation of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF), is thought to...

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Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling

Ling Gao and Giovanni E. Mann.

in Cardiovascular Research

April 2009; p ublished online January 2009 .

Journal Article. Subjects: Cardiovascular Medicine. 7781 words.

Oxidative stress mediated by hyperglycaemia-induced generation of reactive oxygen species (ROS) contributes significantly to the development and progression of diabetes and related vascular...

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Right-sided infective endocarditis

José A. San Román and Javier López.

in The ESC Textbook of Cardiovascular Medicine

December 2018; p ublished online July 2018 .

Chapter. Subjects: Cardiovascular Medicine. 2361 words.

Right-sided infective endocarditis (RSIE) can be classified into three epidemiological groups: intravenous drug users (IDUs), intravascular device carriers, and the ‘three noes’ group (no...

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Calcium-activated transient outward chloride current and phase 1 repolarization of swine ventricular action potential

Gui-Rong Li, Xin-Ling Du, Yaw L. Siow, Karmin O, Hung-Fat Tse and Chu-Pak Lau.

in Cardiovascular Research

April 2003; p ublished online April 2003 .

Journal Article. Subjects: Cardiovascular Medicine. 5452 words.

Abstract

Objective: It is unknown whether 4-aminopyridine- (4-AP-) sensitive transient outward K+ current (I to1) and/or Ca2+-activa...

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NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure

Colin E. Murdoch, Min Zhang, Alison C. Cave and Ajay M. Shah.

in Cardiovascular Research

July 2006; p ublished online July 2006 .

Journal Article. Subjects: Cardiovascular Medicine. 6814 words.

Abstract

Markers of increased oxidative stress are known to be elevated following acute myocardial infarction and in the context of chronic left ventricular...

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New concepts in reactive oxygen species and cardiovascular reperfusion physiology

Lance B Becker.

in Cardiovascular Research

February 2004; p ublished online February 2004 .

Journal Article. Subjects: Cardiovascular Medicine. 6393 words.

Abstract

Increasingly complex behavior of free radicals and reactive oxygen species (ROS) are noted within biological systems. Classically free radicals and...

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Exploration of human, rat, and rabbit embryonic cardiomyocytes suggests K-channel block as a common teratogenic mechanism

Christian Danielsson, Johan Brask, Anna-Carin Sköld, Rami Genead, Agneta Andersson, Ulf Andersson, Kenneth Stockling, Rickard Pehrson, Karl-Henrik Grinnemo, Sajjad Salari, Heike Hellmold, Bengt Danielsson, Christer Sylvén and Fredrik Elinder.

in Cardiovascular Research

January 2013; p ublished online September 2012 .

Journal Article. Subjects: Cardiovascular Medicine. 4807 words.

Aims

Several drugs blocking the rapidly activating potassium (Kr) channel cause malformations (including cardiac defects) and embryonic death in animal...

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Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells

Hong-Jye Hong, Paul Chan, Ju-Chi Liu, Shu-Hui Juan, Meng-Ting Huang, Jaung-Geng Lin and Tzu-Hurng Cheng.

in Cardiovascular Research

January 2004; p ublished online January 2004 .

Journal Article. Subjects: Cardiovascular Medicine. 5855 words.

Abstract

Objective: Angiotensin II (Ang II) increases vascular endothelin-1 (ET-1) tissue levels, which in turn mediate a major part of Ang...

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Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats

Cameron G. McCarthy, Camilla F. Wenceslau, Styliani Goulopoulou, Safia Ogbi, Babak Baban, Jennifer C. Sullivan, Takayuki Matsumoto and R. Clinton Webb.

in Cardiovascular Research

July 2015; p ublished online April 2015 .

Journal Article. Subjects: Cardiovascular Medicine. 7272 words.

Aims

Immune system activation is a common feature of hypertension pathogenesis. However, the mechanisms that initiate this activation are not well...

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Lack of a pharmacologic interaction between ATP-sensitive potassium channels and adenosine A1 receptors in ischemic rat hearts

Gary J. Grover, Anne J. Baird and Paul G. Sleph.

in Cardiovascular Research

April 1996 .

Journal Article. Subjects: Cardiovascular Medicine. 0 words.

Abstract

Objectives: An interaction between adenosine A1 receptors and ATP-sensitive potassium channels (KATP) has been hypothesized to mediate...

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MDL-28170, a membrane-permeant calpain inhibitor, attenuates stunning and PKCε proteolysis in reperfused ferret hearts

Ferdinand Urthaler, Paul E Wolkowicz, Stanley B Digerness, Kevin D Harris and Alfred A Walker.

in Cardiovascular Research

July 1997; p ublished online July 1997 .

Journal Article. Subjects: Cardiovascular Medicine. 5225 words.

Abstract

Objectives: This paper tests the hypothesis that calpains are activated in the ischemic (I)/reperfused (R) heart and contribute to...

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Endothelial protective effects of preconditioning

Karine Laude, Philippe Beauchamp, Christian Thuillez and Vincent Richard.

in Cardiovascular Research

August 2002; p ublished online August 2002 .

Journal Article. Subjects: Cardiovascular Medicine. 5240 words.

Abstract

The consequences of cardiac ischemia–reperfusion are not limited to myocytes but also extend to the coronary endothelium, where they are...

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Mitochondrial KATP channels: role in cardioprotection

Olaf Oldenburg, Michael V Cohen, Derek M Yellon and James M Downey.

in Cardiovascular Research

August 2002; p ublished online August 2002 .

Journal Article. Subjects: Cardiovascular Medicine. 6074 words.

Abstract

The role of the mitochondrial ATP-sensitive potassium channel (mKATP) in ischemic preconditioning and cardioprotection is reviewed. A great deal of...

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Reactive oxygen species mediate cyclooxygenase-2 induction during monocyte to macrophage differentiation: critical role of NADPH oxidase

Silvia Stella Barbieri, Sonia Eligini, Marta Brambilla, Elena Tremoli and Susanna Colli.

in Cardiovascular Research

October 2003; p ublished online October 2003 .

Journal Article. Subjects: Cardiovascular Medicine. 5437 words.

Abstract

Objective: The objective of this study was to explore the relationship between monocyte differentiation into macrophages and...

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Different effects of long- and short-acting loop diuretics on survival rate in Dahl high-salt heart failure model rats

Junichi Yoshida, Kazuhiro Yamamoto, Toshiaki Mano, Yasushi Sakata, Mayu Nishio, Tomohito Ohtani, Masatsugu Hori, Takeshi Miwa and Tohru Masuyama.

in Cardiovascular Research

October 2005; p ublished online October 2005 .

Journal Article. Subjects: Cardiovascular Medicine. 5731 words.

Abstract

Objectives: We compared therapeutic effects of furosemide, a short-acting loop diuretic, and azosemide, a long-acting one, in...

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Role of mitochondria in angiotensin II-induced reactive oxygen species and mitogen-activated protein kinase activation

Guo-Xing Zhang, Xiao-Mei Lu, Shoji Kimura and Akira Nishiyama.

in Cardiovascular Research

November 2007; p ublished online November 2007 .

Journal Article. Subjects: Cardiovascular Medicine. 6828 words.

Abstract

Peptide hormone Angiotensin II (Ang II) activates NAD(P)H oxidase, via AT1 receptors leading to increased generation of reactive oxygen species...

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Beneficial effects of bisoprolol on the survival of hypertensive diastolic heart failure model rats

Mayu Nishio, Yasushi Sakata, Toshiaki Mano, Tomohito Ohtani, Yasuharu Takeda, Takeshi Miwa, Masatsugu Hori, Tohru Masuyama, Takashi Kondo and Kazuhiro Yamamoto.

in European Journal of Heart Failure

May 2008; p ublished online May 2008 .

Journal Article. Subjects: Cardiovascular Medicine. 4100 words.

Background:

β-blocker therapy is an established therapeutic strategy for systolic heart failure. However, its benefits in diastolic heart failure (DHF) are...

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CFTR chloride channels in human and simian heart

John D. Warth, Mei Lin Collier, Pádraig Hart, Yvonne Geary, Craig H. Gelband, Todd Chapman, Burton Horowitz and Joseph R. Hume.

in Cardiovascular Research

April 1996 .

Journal Article. Subjects: Cardiovascular Medicine. 0 words.

Abstract

Objectives: The cAMP-dependent Cl conductance in heart is believed to be due to cardiac expression of the cystic fibrosis...

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