Oxford Index Search Results

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sensitive species

Overview page. Subjects: Environmental Science.

Plant or animal species which are susceptible to changes in habitat or to impacts from human activities.

See overview in Oxford Index

Cytokinesis-block micronucleus assay in WIL2-NS cells: a sensitive system to detect chromosomal damage induced by reactive oxygen species and activated human neutrophils

Keizo Umegaki and Michael Fenech.

in Mutagenesis

May 2000; p ublished online May 2000 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Genetics and Genomics. 7643 words.

We have developed a method that can detect the DNA-damaging and cytotoxic effects of physiological levels of reactive oxygen species (ROS) and activated human neutrophils. This was achieved...

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Interspecies comparison of liver carcinogenesis: implications for cancer risk assessment.

J W Grisham.

in Carcinogenesis

January 1997; p ublished online January 1997 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 0 words.

The morphology of hepatocellular carcinoma is similar among mice, rats and humans, and the cellular pathogenesis shows features that are both similar and divergent among these species....

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Induction and repair inhibition of oxidative DNA damage by nickel(II) and cadmium(II) in mammalian cells.

H Dally and A Hartwig.

in Carcinogenesis

May 1997; p ublished online May 1997 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 0 words.

Compounds of nickel(II) and cadmium(II) are carcinogenic to humans and to experimental animals. One frequently discussed mechanism involved in tumor formation is an increase in reactive...

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Manganese superoxide dismutase expression inhibits soft agar growth in JB6 clone41 mouse epidermal cells.

P A Amstad, H Liu, M Ichimiya, I K Berezesky and B F Trump.

in Carcinogenesis

March 1997; p ublished online March 1997 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 0 words.

Manganese superoxide dismutase (MnSOD) has been found to be depleted in a variety of tumor cells as well as in in vitro transformed cell lines, suggesting that MnSOD may function as an...

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Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al2O3) nanoparticles in mouse skin epithelial cells

Swatee Dey, Vasudevan Bakthavatchalu, Michael T. Tseng, Peng Wu, Rebecca L. Florence, Eric A. Grulke, Robert A. Yokel, Sanjit Kumar Dhar, Hsin-Sheng Yang, Yumin Chen and Daret K. St Clair.

in Carcinogenesis

October 2008; p ublished online August 2008 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 6569 words.

The physicochemical properties of nanomaterials differ from those of the bulk material of the same composition. However, little is known about the underlying effects of these particles in...

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The multiplicative model for cancer risk assessment: applicability to acrylamide

B. Paulsson, F. Granath, J. Grawé, L. Ehrenberg and M. Törnqvist.

in Carcinogenesis

May 2001; p ublished online May 2001 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 2294 words.

According to a multiplicative model for prediction of cancer risk for genotoxic agents the incremental cancer risk is, for low–intermediate exposures, proportional to target doses of the...

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Induction of oxidative DNA damage by arsenite and its trivalent and pentavalent methylated metabolites in cultured human cells and isolated DNA

Tanja Schwerdtle, Ingo Walter, Iris Mackiw and Andrea Hartwig.

in Carcinogenesis

May 2003; p ublished online May 2003 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 6401 words.

Even though a well-known human carcinogen the underlying mechanisms of arsenic carcinogenicity are still not fully understood. For arsenite, proposed mechanisms are the interference with DNA...

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32P-postlabeling high-performance liquid chromatography (32P-HPLC) adapted for analysis of 8-hydroxy-2′-deoxyguanosine

Magnus Zeisig, Tim Hofer, Jean Cadet and Lennart Möller.

in Carcinogenesis

July 1999; p ublished online July 1999 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 3967 words.

8-Hydroxy-2′-deoxyguanosine (8-OH-dG) is a promutagenic lesion in DNA caused by reactive oxygen species. It normally exists at a level of 0.1–1 per 105 2′-deoxyguanosines (dG). To analyze...

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Simultaneous generation of multiple mitochondrial DNA mutations in human prostate tumors suggests mitochondrial hyper-mutagenesis

Junjian Z. Chen, Neriman Gokden, Graham F. Greene, Bridgett Green and Fred F. Kadlubar.

in Carcinogenesis

September 2003; p ublished online September 2003 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 4848 words.

Multiple somatic mitochondrial DNA mutations are frequently reported in human tumors, but the process leading to homoplasmic transformation and accumulation of multiple mutations in the same...

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MAP17 inhibits Myc-induced apoptosis through PI3K/AKT pathway activation

Maria V. Guijarro, Wolfgang Link, Aránzazu Rosado, Juan F.M. Leal and Amancio Carnero.

in Carcinogenesis

December 2007; p ublished online August 2007 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 5228 words.

MAP17 is a non-glycosylated membrane-associated protein that has been shown to be over-expressed in human carcinomas, suggesting a possible role of this protein in tumorigenesis. However,...

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SAG/ROC2/RBX2 E3 ligase promotes UVB-induced skin hyperplasia, but not skin tumors, by simultaneously targeting c-Jun/AP-1 and p27

Hongbin He, Qingyang Gu, Min Zheng, Daniel Normolle and Yi Sun.

in Carcinogenesis

April 2008; p ublished online February 2008 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 5611 words.

Sensitive to apoptosis gene (SAG)/regulator of cullins-2/RING box protein 2 is a stress-responsive RING component of Skp-1/Cullins/F-box protein E3 ubiquitin ligase. When overexpressed, SAG...

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PLAB induction in fenretinide-induced apoptosis of ovarian cancer cells occurs via a ROS-dependent mechanism involving ER stress and JNK activation

Valentina Appierto, Paola Tiberio, Maria Grazia Villani, Elena Cavadini and Franca Formelli.

in Carcinogenesis

May 2009; p ublished online March 2009 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 5624 words.

Fenretinide [N-(4-hydroxyphenyl)-retinamide (4HPR)] is a synthetic retinoid with antitumor activity that induces apoptosis in various types of cancer cell. We showed previously that 4HPR...

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Biological consequences of DNA damage introduced in bacteriophage PM2 DNA by hydrogen peroxide-mediated free radial reactions

Johan J.P. Gille, Natasja M. Wientjes, M.Vincent M. Lafleur, Hans Joenje and Jan Retèl.

in Carcinogenesis

January 1996 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 0 words.

In order to study the biological consequences of DNA damage induced by H2O2-mediated free radical reactions, DNA from bacteriophage PM2 was exposed to H2O2, Fe3+-citrate and ascorbate...

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Effect of tamoxifen feeding on metabolic activation of tamoxifen by the liver of the Rhesus monkey: Does liver accumulation of inhibitory metabolities protect from tamoxifen-dependent genotoxicity and cancer?

Adriana Comoglio, Anthony H. Gibbs, Ian N.H. White, Timothy Gant, Elizabeth A. Martin, Lewis L. Smith, Silvana Ricci Gamalero and Francesco DeMatteis.

in Carcinogenesis

August 1996 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 0 words.

Tamoxifen induces hepatocellular carcinomas in rats and is converted by rat hepatic cytochrome P450 enzymes into reactive metabolites capable of forming adducts with nucleic acids, proteins...

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TCDD activates Mdm2 and attenuates the p53 response to DNA damaging agents

Gerd Pääjärvi, Matti Viluksela, Raimo Pohjanvirta, Ulla Stenius and Johan Högberg.

in Carcinogenesis

January 2005; p ublished online January 2005 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 5697 words.

In this study we investigated the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the p53 response to DNA damaging agents. Pre-treatment of rats with TCDD attenuated the p53 liver...

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Absence of full-length Brca1 sensitizes mice to oxidative stress and carcinogen-induced tumorigenesis in the esophagus and forestomach

Liu Cao, Xiaoling Xu, Longyue L. Cao, Rui-Hong Wang, Xavier Coumoul, Sang S. Kim and Chu-Xia Deng.

in Carcinogenesis

July 2007; p ublished online March 2007 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 4239 words.

Environmental and genetic factors are important both in affecting life span and neoplastic transformation. We have shown previously that mice, which are homozygous for full-length breast...

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Potential role of ferritin heavy chain in oxidative stress and apoptosis in human mesothelial and mesothelioma cells: implications for asbestos-induced oncogenesis

Winn Aung, Sumitaka Hasegawa, Takako Furukawa and Tsuneo Saga.

in Carcinogenesis

September 2007; p ublished online April 2007 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 5046 words.

Exposure to asbestos is a known etiological factor in malignant mesothelioma (MM). However, in vitro cell culture studies have provided paradoxical evidence that asbestos exposure to...

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Studies of the mechanism by which increased spermidine/spermine N 1-acetyltransferase activity increases susceptibility to skin carcinogenesis

Xiaojing Wang, David J. Feith, Pat Welsh, Catherine S. Coleman, Christina Lopez, Patrick M. Woster, Thomas G. O'Brien and Anthony E. Pegg.

in Carcinogenesis

November 2007; p ublished online August 2007 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 6003 words.

Previous studies have shown that keratin 6 (K6)–spermidine/spermine N 1-acetyltransferase (SSAT) transgenic mice, which modestly over-express SSAT in the skin, are more...

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Increased gene expression in human promyeloid leukemia cells exposed to trans,trans-muconaldehyde, a hematotoxic benzene metabolite.

T Y Ho and G Witz.

in Carcinogenesis

April 1997; p ublished online April 1997 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 0 words.

The hematotoxicity of benzene, a human leukemogen, has been postulated to be mediated by reactive metabolites and involve cell damage caused by reactive oxygen species. Because expression...

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Degradation of NF-κB, p53 and other regulatory redox-sensitive proteins by thiol-conjugating and -nitrosylating drugs in human tumor cells

Ameya Paranjpe and Kalkunte S. Srivenugopal.

in Carcinogenesis

May 2013; p ublished online January 2013 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 8765 words.

The ionized cysteines present on the surfaces of many redox-sensitive proteins play functionally essential roles and are readily targeted by the reactive oxygen and reactive nitrogen...

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