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sensitive species x Toxicology (Non-medical) x clear all

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sensitive species

Overview page. Subjects: Environmental Science.

Plant or animal species which are susceptible to changes in habitat or to impacts from human activities.

See overview in Oxford Index

Hepatic Vitamin A Depletion Is a Sensitive Marker of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Exposure in Four Rodent Species

Nicholas Fletcher, Annika Hanberg and Helen Håkansson.

in Toxicological Sciences

July 2001; p ublished online July 2001 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8379 words.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-treated animals show altered retinoid homeostasis and exhibit signs of toxicity similar to those of vitamin A–deficient animals. In this study we...

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Evaluation of Two Novel Peptide Safety Markers for Exocrine Pancreatic Toxicity

Jennie L. Walgren, Michael D. Mitchell, Laurence O. Whiteley and David C. Thompson.

in Toxicological Sciences

March 2007; p ublished online December 2006 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 5492 words.

Current markers of exocrine pancreatic toxicity have historically been poor indicators for both early diagnosis of disease and prediction of disease severity. Recently we identified two...

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Cross-species Comparisons of Transcriptomic Alterations in Human and Rat Primary Hepatocytes Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Michael B. Black, Robert A. Budinsky, Alan Dombkowski, Daniela Cukovic, Edward L. LeCluyse, Stephen S. Ferguson, Russell S. Thomas and J. Craig Rowlands.

in Toxicological Sciences

May 2012; p ublished online February 2012 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 9886 words.

A toxicogenomics approach was used to qualitatively and quantitatively compare the gene expression changes in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxi...

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Sensitivity of Japanese Quail (Coturnix japonica), Common Pheasant (Phasianus colchicus), and White Leghorn Chicken (Gallus gallus domesticus) Embryos to In Ovo Exposure to TCDD, PeCDF, and TCDF

Andrew M. Cohen-Barnhouse, Matthew J. Zwiernik, Jane E. Link, Scott D. Fitzgerald, Sean W. Kennedy, Jessica C. Hervé, John P. Giesy, Steve Wiseman, Yinfei Yang, Paul D. Jones, Yi Wan, Brian Collins, John L. Newsted, Denise Kay and Steven J. Bursian.

in Toxicological Sciences

January 2011; p ublished online September 2010 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 5969 words.

Egg injection studies were performed to confirm a proposed model of relative sensitivity of birds to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In this model, species are classified as...

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Peroxisome Proliferators Do Not Activate the Transcription Factors AP-1, Early Growth Response-1, or Heat Shock Factors 1 and 2 in Rats or Hamsters

Michelle L. O'Brien, Michael L. Cunningham, Brett T. Spear and Howard P. Glauert.

in Toxicological Sciences

September 2002; p ublished online September 2002 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8808 words.

Peroxisome proliferators (PPs) cause hepatomegaly, peroxisome proliferation, and hepatocarcinogenesis in rats and mice, whereas hamsters are less responsive to these compounds. PPs increase...

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Comparative Metabolism and Excretion of Benzo(a)pyrene in 2 Species of Ictalurid Catfish

Kristine L. Willett, Piero R. Gardinali, Laila A. Lienesch and Richard T. Di Giulio.

in Toxicological Sciences

November 2000; p ublished online November 2000 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7133 words.

Differential susceptibility of polycyclic aromatic hydrocarbon (PAH)-mediated liver cancer exists in two related species of Ictalurid catfish. Two hypotheses are addressed in this study to...

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Multi-species Analyses of Direct Activators of the Constitutive Androstane Receptor

Curtis J. Omiecinski, Denise M. Coslo, Tao Chen, Elizabeth M. Laurenzana and Richard C. Peffer.

in Toxicological Sciences

October 2011; p ublished online July 2011 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7956 words.

The constitutive androstane receptor (CAR; NR1I3) is a member of the nuclear receptor superfamily and functions as an important xenochemical sensor and transcriptional modulator in...

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Cytochrome P4501A Induction by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Two Chlorinated Dibenzofurans in Primary Hepatocyte Cultures of Three Avian Species

Jessica C. Hervé, Doug Crump, Stephanie P. Jones, Lukas J. Mundy, John P. Giesy, Matthew J. Zwiernik, Steven J. Bursian, Paul D. Jones, Steve B. Wiseman, Yi Wan and Sean W. Kennedy.

in Toxicological Sciences

February 2010; p ublished online November 2009 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6937 words.

Relative potencies of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), and 2,3,7,8-tetrachlorodibenzofuran (TCDF) were determined in vitro in primary...

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µLC–ICP-MS Determinations of Unexposed UK Urinary Arsenic Speciation Reference Values

Elizabeth Leese, Jackie Morton, Emma Tan, Philip H.E. Gardiner and Vikki A. Carolan.

in Journal of Analytical Toxicology

January 2014; p ublished online January 2014 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 4628 words.

This study provides background levels for five arsenic species in urine, based on urinary data obtained from 95 nonoccupationally exposed volunteers based in the UK. Using a novel,...

Go to Oxford Journals »  full text: open access   » abstract

Differential Activation of Hepatic NF-κB in Rats and Hamsters by the Peroxisome Proliferators Wy-14,643, Gemfibrozil, and Dibutyl Phthalate

Job C. Tharappel, Michael L. Cunningham, Brett T. Spear and Howard P. Glauert.

in Toxicological Sciences

July 2001; p ublished online July 2001 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 4563 words.

Nuclear factor-κB (NF-κB) is an oxidative stress-activated transcription factor involved in the regulation of cell proliferation and apoptosis. We found previously that the peroxisome...

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Human and Rat Primary Hepatocyte CYP1A1 and 1A2 Induction with 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,3,7,8-Tetrachlorodibenzofuran, and 2,3,4,7,8-Pentachlorodibenzofuran

Robert A. Budinsky, Edward L. LeCluyse, Stephen S. Ferguson, J. Craig Rowlands and Ted Simon.

in Toxicological Sciences

November 2010; p ublished online August 2010 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6606 words.

The concentration dose response for aryl hydrocarbon receptor (AHR)-mediated CYP1A1 and CYP1A2 messenger RNA (mRNA) induction and enzyme activity was determined in primary cultures of rat...

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A Highly Sensitive Spectrophotometric Method with Solid-Phase Extraction for the Determination of Methylmercury in Human Hair

Hua-Bin Li, Feng Chen and Xiang-Rong Xu.

in Journal of Analytical Toxicology

November 2000; p ublished online November 2000 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

Methylmercury is the most toxic among the mercury species. In order to provide a quick method to screen samples for methylmercury, a highly sensitive spectrophotometric method was...

Go to Oxford Journals »  abstract

Quantitative Comparisons of the Acute Neurotoxicity of Toluene in Rats and Humans

Vernon A. Benignus, William K. Boyes, Elaina M. Kenyon and Philip J. Bushnell.

in Toxicological Sciences

November 2007; p ublished online August 2007 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6222 words.

The behavioral and neurophysiological effects of acute exposure to toluene are the most thoroughly explored of all the hydrocarbon solvents. Behavioral effects have been experimentally...

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Application of a Hybrid CFD-PBPK Nasal Dosimetry Model in an Inhalation Risk Assessment: An Example with Acrylic Acid

Melvin Andersen, Ramesh Sarangapani, Robinan Gentry, Harvey Clewell, Tammie Covington and Clay B. Frederick.

in Toxicological Sciences

October 2000; p ublished online October 2000 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 9574 words.

The available inhalation toxicity information for acrylic acid (AA) suggests that lesions to the nasal cavity, specifically olfactory degeneration, are the most sensitive end point for...

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Issues in Risk Assessment for Developmental Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Compounds

Lesa L. Aylward, James C. Lamb and Steven C. Lewis.

in Toxicological Sciences

September 2005; p ublished online June 2005 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 5460 words.

Recent risk assessments for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds have focused on adverse effects observed in rodent offspring exposed while in utero during...

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Nonclinical Safety Evaluation of Muraglitazar, a Novel PPARα/γ Agonist

Crystal R. Waites, Mark A. Dominick, Thomas P. Sanderson and Beth E. Schilling.

in Toxicological Sciences

November 2007; p ublished online August 2007 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7081 words.

The toxicity of muraglitazar, an oxybenzylglycine, nonthiazolidinedione peroxisome proliferator–activated receptor (PPAR) α/γ agonist, was evaluated in a comprehensive nonclinical...

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Evaluation of Mass Spectrometric Methods for Detection of the Anti-Protozoal Drug Imidocarb*

A.F. Lehner, J.A. Hitron, J. May, C. Hughes, R. Eisenberg, N. Schwint, D.P. Knowles, P. Timoney and T. Tobin.

in Journal of Analytical Toxicology

May 2011; p ublished online May 2011 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

Imidocarb [N,N′-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea, C19H20N6O1, m.w. 348.41] is a symmetrical carbanilide derivative used to treat disease caused by protozoans of the Babesia g...

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Persistent Adverse Effects on Health and Reproduction Caused by Exposure of Zebrafish to 2,3,7,8-Tetrachlorodibenzo-p-dioxin During Early Development and Gonad Differentiation

Tisha C. King Heiden, Jan Spitsbergen, Warren Heideman and Richard E. Peterson.

in Toxicological Sciences

May 2009; p ublished online March 2009 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8547 words.

Little is understood regarding the impacts of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure during early development on the health, survival, and reproductive capability of adults....

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Novel Application of Human Neurons Derived from Induced Pluripotent Stem Cells for Highly Sensitive Botulinum Neurotoxin Detection

Regina C. M. Whitemarsh, Monica J. Strathman, Lucas G. Chase, Casey Stankewicz, William H. Tepp, Eric A. Johnson and Sabine Pellett.

in Toxicological Sciences

April 2012; p ublished online January 2012 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6472 words.

Human induced pluripotent stem cells (hiPSC) hold great promise for providing various differentiated cell models for in vitro toxigenicity testing. For Clostridium botulinum neurotoxin...

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Chloroform Inhalation Exposure Conditions Necessary to Initiate Liver Toxicity in Female B6C3F1 Mice

Alexander A. Constan, Brian A. Wong, Jeffrey I. Everitt and Byron E. Butterworth.

in Toxicological Sciences

April 2002; p ublished online April 2002 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6450 words.

Chloroform is a nongenotoxic-cytotoxic carcinogen in rodent liver and kidney, including the female B6C3F1 mouse liver. Because tumors are secondary to events associated with cytolethality...

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