Dose-Incidence Modeling: Consequences of Linking Quantal Measures of Response to Depletion of Critical Tissue Targets
in Toxicological Sciences
January 2006; p ublished online October 2005 .
Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 4528 words.
In developing mechanistic PK–PD models, incidence of toxic responses in a population has to be described in relation to measures of biologically effective dose (BED). We have developed a...