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virus x Neuropathology x clear all

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virus

Overview page. Subjects: Computing.

Program code written to replicate by attaching copies of itself to other objects within the system, and normally also having a detrimental effect. This may range from generation of...

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Zika virus-associated neurological disorders: a review

Abelardo Q. C. Araujo, Marcus Tulius T. Silva and Alexandra P. Q. C. Araujo.

in Brain

August 2016; p ublished online June 2016 .

Journal Article. Subjects: Sensory and Motor Systems; Neuropathology; Disorders of the Nervous System. 6055 words.

Zika virus, an arbovirus transmitted by mosquitoes of the Aedes species, is now rapidly disseminating throughout the Americas and the ongoing Brazilian outbreak is the largest Zika virus...

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A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency

Julie Tordo, Claire O’Leary, André S L M Antunes, Nuria Palomar, Patrick Aldrin-Kirk, Mark Basche, Antonette Bennett, Zelpha D’Souza, Hélène Gleitz, Annie Godwin, Rebecca J Holley, Helen Parker, Ai Yin Liao, Paul Rouse, Amir Saam Youshani, Larbi Dridi, Carla Martins, Thierry Levade, Kevin B Stacey, Daniel M Davis, Adam Dyer, Nathalie Clément, Tomas Björklund, Robin R Ali, Mavis Agbandje-McKenna, Ahad A Rahim, Alexey Pshezhetsky, Simon N Waddington, R Michael Linden, Brian W Bigger and Els Henckaerts.

in Brain

July 2018; p ublished online May 2018 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 10454 words.

Abstract

Recombinant adeno-associated viruses (AAVs) are popular in vivo gene transfer vehicles. However, vector doses needed to achieve therapeutic effect are...

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CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease

Lydie Boussicault, Sandro Alves, Antonin Lamazière, Anabelle Planques, Nicolas Heck, Lara Moumné, Gaëtan Despres, Susanne Bolte, Amélie Hu, Christiane Pagès, Laurie Galvan, Francoise Piguet, Patrick Aubourg, Nathalie Cartier, Jocelyne Caboche and Sandrine Betuing.

in Brain

March 2016; p ublished online January 2016 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 9579 words.

Huntington’s disease is an autosomal dominant neurodegenerative disease caused by abnormal polyglutamine expansion in huntingtin (Exp-HTT) leading to degeneration of striatal neurons....

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TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson’s disease via CNTF

Jin H. Nam, Eun S. Park, So-Yoon Won, Yu A. Lee, Kyoung I. Kim, Jae Y. Jeong, Jeong Y. Baek, Eun J. Cho, Minyoung Jin, Young C. Chung, Byoung D. Lee, Sung Hyun Kim, Eung-Gook Kim, Kyunghee Byun, Bonghee Lee, Dong Ho Woo, C. Justin Lee, Sang R. Kim, Eugene Bok, Yoon-Seong Kim, Tae-Beom Ahn, Hyuk Wan Ko, Saurav Brahmachari, Olga Pletinkova, Juan C. Troconso, Valina L. Dawson, Ted M. Dawson and Byung K. Jin.

in Brain

December 2015; p ublished online October 2015 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 6263 words.

Currently there is no neuroprotective or neurorestorative therapy for Parkinson’s disease. Here we report that transient receptor potential vanilloid 1 (TRPV1) on astrocytes mediates...

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Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat

Marie d’Orange, Gwénaelle Aurégan, Dimitri Cheramy, Mylène Gaudin-Guérif, Sarah Lieger, Martine Guillermier, Lev Stimmer, Charlène Joséphine, Anne-Sophie Hérard, Marie-Claude Gaillard, Fanny Petit, Maren Christine Kiessling, Christoph Schmitz, Morvane Colin, Luc Buée, Fany Panayi, Elsa Diguet, Emmanuel Brouillet, Philippe Hantraye, Alexis-Pierre Bemelmans and Karine Cambon.

in Brain

February 2018; p ublished online December 2017 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 8578 words.

Abstract

Tauopathies are neurodegenerative diseases characterized by the aggregation of tau protein. These pathologies exhibit a wide variety of clinical and...

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CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

Fathia Djelti, Jerome Braudeau, Eloise Hudry, Marc Dhenain, Jennifer Varin, Ivan Bièche, Catherine Marquer, Farah Chali, Sophie Ayciriex, Nicolas Auzeil, Sandro Alves, Dominique Langui, Marie-Claude Potier, Olivier Laprevote, Michel Vidaud, Charles Duyckaerts, Richard Miles, Patrick Aubourg and Nathalie Cartier.

in Brain

August 2015; p ublished online July 2015 .

Journal Article. Subjects: Disorders of the Nervous System; Neuropathology. 9514 words.

Abnormalities in neuronal cholesterol homeostasis have been suspected or observed in several neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease and Huntington’s...

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Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy

Megan S. Keiser, Jeffrey H. Kordower, Pedro Gonzalez-Alegre and Beverly L. Davidson.

in Brain

December 2015; p ublished online October 2015 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 5367 words.

Spinocerebellar ataxia type 1 is one of nine polyglutamine expansion diseases and is characterized by cerebellar ataxia and neuronal degeneration in the cerebellum and brainstem. Currently,...

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Liver transplant in ethylmalonic encephalopathy: a new treatment for an otherwise fatal disease

Carlo Dionisi-Vici, Daria Diodato, Giuliano Torre, Stefano Picca, Rosanna Pariante, Sergio Giuseppe Picardo, Ivano Di Meo, Cristiano Rizzo, Valeria Tiranti, Massimo Zeviani and Jean De Ville De Goyet.

in Brain

April 2016; p ublished online February 2016 .

Journal Article. Subjects: Sensory and Motor Systems; Neuropathology; Disorders of the Nervous System. 3059 words.

Ethylmalonic encephalopathy is a fatal, rapidly progressive mitochondrial disorder caused by ETHE1 mutations, whose peculiar clinical and biochemical features are due to the toxic...

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