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virus

Overview page. Subjects: Computing.

Program code written to replicate by attaching copies of itself to other objects within the system, and normally also having a detrimental effect. This may range from generation of...

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A fusogenic dengue virus-derived peptide enhances antitumor efficacy of an antibody–ribonuclease fusion protein targeting the EGF receptor

Stefan Kiesgen, Nora Liebers, Martin Cremer, Ulrich Arnold, Tobias Weber, Armin Keller, Christel Herold-Mende, Gerhard Dyckhoff, Dirk Jäger, Roland E. Kontermann, Michaela A. E. Arndt and Jürgen Krauss.

in Protein Engineering, Design and Selection

October 2014; p ublished online October 2014 .

Journal Article. Subjects: Proteins. 4025 words.

Due to its frequent overexpression in a variety of solid tumors the epidermal growth factor receptor (EGFR) is a well-established target for therapeutic interventions in epithelial cancers....

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Virus engineering: functionalization and stabilization

Mauricio G. Mateu.

in Protein Engineering, Design and Selection

January 2011; p ublished online October 2010 .

Journal Article. Subjects: Proteins. 8247 words.

Chemically and/or genetically engineered viruses, viral capsids and viral-like particles carry the promise of important and diverse applications in biomedicine, biotechnology and...

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Novel macromolecular inhibitors of human immunodeficiency virus-1 protease

Gabriella Miklóssy, József Tözsér, János Kádas, Rieko Ishima, John M. Louis and Péter Bagossi.

in Protein Engineering, Design and Selection

July 2008; p ublished online May 2008 .

Journal Article. Subjects: Proteins. 5686 words.

An intracellularly expressed defective human immunodeficiency virus type-1 (HIV-1) protease (PR) monomer could function as a dominant-negative inhibitor of the enzyme that requires...

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Binding of external ligands onto an engineered virus capsid

Uli Schmidt, Rainer Rudolph and Gerald Böhm.

in Protein Engineering, Design and Selection

October 2001; p ublished online October 2001 .

Journal Article. Subjects: Proteins. 4343 words.

The development of novel delivery systems for therapeutic substances includes targeting of the carriers to a specific site or tissue within the body of the recipient. This can be...

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Structural investigation of influenza virus hemagglutinin membrane-anchoring peptide

Konstantin S. Mineev, Ekaterina N. Lyukmanova, Ludwig Krabben, Marina V. Serebryakova, Mikhail A. Shulepko, Alexander S. Arseniev, Larisa V. Kordyukova and Michael Veit.

in Protein Engineering, Design and Selection

September 2013; p ublished online July 2013 .

Journal Article. Subjects: Proteins. 3291 words.

Hemagglutinin (HA), the trimeric spike of influenza virus, catalyzes fusion of viral and cellular membranes. We have synthesized the anchoring peptide including the linker, transmembrane...

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Extracellular self-assembly of virus-like particles from secreted recombinant polyoma virus major coat protein

J. Ng, O. Koechlin, M. Ramalho, D. Raman and N. Krauzewicz.

in Protein Engineering, Design and Selection

December 2007; p ublished online November 2007 .

Journal Article. Subjects: Proteins. 6828 words.

Mouse polyoma virus major coat protein (VP1) expressed from a recombinant baculovirus is efficiently transported to infected cell nuclei and assembles into protein nanospheres...

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Modelling the structure of the fusion protein from human respiratory syncytial virus

Brian J. Smith, Michael C. Lawrence and Peter M. Colman.

in Protein Engineering, Design and Selection

May 2002; p ublished online May 2002 .

Journal Article. Subjects: Proteins. 4249 words.

The fusion protein of respiratory syncytial virus (RSV-F) is responsible for fusion of virion with host cells and infection of neighbouring cells through the formation of syncytia. A...

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Metal binding and activation of the ribonuclease H domain from Moloney murine leukemia virus

Eric R. Goedken and Susan Marqusee.

in Protein Engineering, Design and Selection

November 1999; p ublished online November 1999 .

Journal Article. Subjects: Proteins. 4960 words.

The RNase H family of enzymes degrades RNA in RNA˙DNA hybrids in a divalent cation-dependent manner. RNases H from diverse sources such as Escherichia coli and human immunodeficiency virus...

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Endopeptidase activity characterization of E. coli-derived infectious bursal disease virus protein 4 tubules

Gary Ro-Lin Chang, Min-Ying Wang, Jiahn-Haur Liao, Yu-Ping Hsiao and Su-Yuan Lai.

in Protein Engineering, Design and Selection

November 2012; p ublished online October 2012 .

Journal Article. Subjects: Proteins. 4518 words.

Viral protein 4 (VP4) is a serine protease that catalyzes the hydrolysis of polyprotein pVP2-VP4-VP3 of infectious bursal disease virus. In this report, the recombinant VP4 with a His-tag...

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Further increase in thermostability of Moloney murine leukemia virus reverse transcriptase by mutational combination

Misato Baba, Ryota Kakue, Christoph Leucht, Peter Rasor, Heiko Walch, Daniel Ladiges, Christian Bell, Kenji Kojima, Teisuke Takita and Kiyoshi Yasukawa.

in Protein Engineering, Design and Selection

August 2017; p ublished online August 2017 .

Journal Article. Subjects: Proteins. 4562 words.

Abstract

We previously generated a highly thermostable triple variant of Moloney murine leukemia virus reverse transcriptase, MM3 (E286R/E302K/L435R), by...

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Effects of humanization by variable domain resurfacing on the antiviral activity of a single-chain antibody against respiratory syncytial virus

Simon Delagrave, John Catalan, Charles Sweet, Glenn Drabik, Andrew Henry, Anthony Rees, Thomas P. Monath and Farshad Guirakhoo.

in Protein Engineering, Design and Selection

April 1999; p ublished online April 1999 .

Journal Article. Subjects: Proteins. 4556 words.

HNK20 is a mouse monoclonal IgA that binds to the F glycoprotein of respiratory syncytial virus (RSV) and neutralizes the virus, both in vitro and in vivo. The single-chain antibody...

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Design and analysis of post‐fusion 6‐helix bundle of heptad repeat regions from Newcastle disease virus F protein

Jieqing Zhu, Pengyun Li, Tinghe Wu, Feng Gao, Yi Ding, Catherine W.‐H. Zhang, Zihe Rao, George F. Gao and Po Tien.

in Protein Engineering, Design and Selection

May 2003; p ublished online May 2003 .

Journal Article. Subjects: Proteins. 3622 words.

Fusion of paramyxovirus to the cell involves receptor binding of the HN glycoprotein and a number of conformational changes of F glycoprotein. The F protein is expressed as a homotrimer on...

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Identification of human single-chain antibodies with broad reactivity for noroviruses

Wanzhi Huang, Moumita Samanta, Sue E. Crawford, Mary K. Estes, Frederick H. Neill, Robert L. Atmar and Timothy Palzkill.

in Protein Engineering, Design and Selection

October 2014; p ublished online June 2014 .

Journal Article. Subjects: Proteins. 8857 words.

Norovirus infections are a common cause of gastroenteritis and new methods to rapidly diagnose norovirus infections are needed. The goal of this study was to identify antibodies that have...

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Engineering, characterization and phage display of hepatitis C virus NS3 protease and NS4A cofactor peptide as a single-chain protein.

N Dimasi, A Pasquo, F Martin, S Di Marco, C Steinkühler, R Cortese and M Sollazzo.

in Protein Engineering, Design and Selection

December 1998; p ublished online December 1998 .

Journal Article. Subjects: Proteins. 0 words.

The polyprotein encoded by hepatitis C virus (HCV) genomic RNA is processed into functional polypeptides by both host- and virus-encoded proteases. The HCV-encoded NS3 protease and its...

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Effect of mutations on the dimer stability and the pH optimum of the human foamy virus protease

Tamás Sperka, Péter Boross, Helga Eizert, József Tözsér and Péter Bagossi.

in Protein Engineering, Design and Selection

P ublished online June 2006 .

Journal Article. Subjects: Proteins. 4089 words.

To explore the role of residues being close to the catalytic aspartates in the higher pH optimum and in the lower dimer stability of human foamy virus (HFV) protease (PR) in comparison with...

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N-terminal region of P protein of Chandipura virus is responsible for phosphorylation-mediated homodimerization

T. Raha, E. Samal, A. Majumdar, S. Basak, D. Chattopadhyay and D.J. Chattopadhyay.

in Protein Engineering, Design and Selection

June 2000; p ublished online June 2000 .

Journal Article. Subjects: Proteins. 5700 words.

The phosphoprotein P of Chandipura (CHP) virus, an Indian isolate of rhabdovirus, was found to support transcription upon phosphorylation by casein kinase II (CKII). A...

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Dengue virus type 2 envelope protein displayed as recombinant phage attachment protein reveals potential cell binding sites

Juraina Abd-Jamil, Chen-Yee Cheah and Sazaly AbuBakar.

in Protein Engineering, Design and Selection

October 2008; p ublished online July 2008 .

Journal Article. Subjects: Proteins. 5395 words.

A method to map the specific site on dengue virus envelope protein (E) that interacts with cells and a neutralizing antibody is developed using serially truncated dengue virus type 2...

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Transplantation of a hydrogen bonding network from West Nile virus protease onto Dengue-2 protease improves catalytic efficiency and sheds light on substrate specificity

Danny N.P. Doan, Kun Quan Li, Chandrakala Basavannacharya, Subhash G. Vasudevan and M.S. Madhusudhan.

in Protein Engineering, Design and Selection

December 2012; p ublished online September 2012 .

Journal Article. Subjects: Proteins. 4953 words.

The two-component serine protease of flaviviruses such as Dengue virus (DENV) and West Nile virus (WNV) are attractive targets for inhibitor/therapeutic design. Peptide aldehyde inhibitors...

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Optimized sequential purification protocol for in vivo site-specific biotinylated full-length dengue virus capsid protein

Mun Keat Chong, Krupakar Parthasarathy, Hui Yu Yeo and Mah Lee Ng.

in Protein Engineering, Design and Selection

May 2013; p ublished online March 2013 .

Journal Article. Subjects: Proteins. 6263 words.

Dengue virus (DENV) capsid (C) protein is one of the three structural proteins that form a mature virus. The main challenge impeding the study of this protein is to generate pure...

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Analysis of IgG heavy chain to light chain ratio with mutant Encephalomyocarditis virus internal ribosome entry site

Jiandong Li, Congcong Zhang, Thomas Jostock and Stefan Dübel.

in Protein Engineering, Design and Selection

October 2007; p ublished online October 2007 .

Journal Article. Subjects: Proteins. 4282 words.

Immunoglobulin G (IgG) is a heterotetrameric protein assembled from two identical heavy chain (HC) and two identical light chain (LC) polypeptides. The HC and LC folding and assembly are a...

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