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virus

Overview page. Subjects: Computing.

Program code written to replicate by attaching copies of itself to other objects within the system, and normally also having a detrimental effect. This may range from generation of...

See overview in Oxford Index

Treatment of medulloblastoma with a modified measles virus

Adam W. Studebaker, Cole R. Kreofsky, Christopher R. Pierson, Stephen J. Russell, Evanthia Galanis and Corey Raffel.

in Neuro-Oncology

October 2010; p ublished online May 2010 .

Journal Article. Subjects: Medical Oncology; Neurology. 4941 words.

Although treatment of medulloblastoma has improved, at least 30% of patients with this tumor die of progressive disease. Unfortunately, many of the children who survive suffer long-term...

Go to »  abstract

Glioma virus therapies between bench and bedside

Johanna K. Kaufmann and E. Antonio Chiocca.

in Neuro-Oncology

March 2014; p ublished online January 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 12575 words.

Despite extensive research, current glioma therapies are still unsatisfactory, and novel approaches are pressingly needed. In recent years, both nonreplicative viral vectors and replicating...

ET-40ONCOLYTIC VIRUS INDUCED HMGB1 SECRETION AND ITS IMPACT ON TUMOR ANGIOGENESIS

Kamaldeen Muili, Chelsea Bolyard, Cristina Jaime-Ramirez, Ji Young Yoo and Balveen Kaur.

in Neuro-Oncology

November 2014; p ublished online November 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Glioblastoma multiforme (GBM) is a difficult-to-treat, and the most aggressive of primary brain tumors. Survival is less than 2 years despite aggressive therapy. Oncolytic virus (OV)...

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P17.58DETECTION OF HUMAN PAPILLOMA VIRUS DNA IN A SUBSET OF GLIOBLASTOMA SAMPLES

G. Gasparre, M. Vidone, M. Cricca, C. Savini, E. Trevisan, R. Soffietti, G. Faccani, M. Leone and I. Morra.

in Neuro-Oncology

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

BACKGROUND: Glioblastoma Multiforme (GBM) is the most common malignant brain tumor in adults, but its aetiology remains unknown. Recent reports have demonstrated the presence of neurotropic...

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IMMU-73. GLIOMA IN SITU VACCINATION WITH COWPEA MOSAIC VIRUS NANOPARTICLES

Amber Kerstetter-Fogle, Sourabh Shukla, Veronique Beiss, Peggy Harris, Andrew Sloan and Nicole Steinmetz.

in Neuro-Oncology

November 2018; p ublished online November 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Glioblastoma multiforme is the most malignant brain cancer affecting adults. Despite recent advancements, the current prognosis is dismal with median...

NT-17TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) WITH AN ONCOLYTIC MEASLES VIRUS IN COMBINATION WITH INHIBITORS OF THE PI3-KINASE PATHWAY

Sangeet Lal, Samuel Lawrence and Corey Raffel.

in Neuro-Oncology

November 2014; p ublished online November 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is a highly malignant pediatric brainstem tumor with less than 10% of patients surviving beyond 2 years. Surgical resection of this...

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IMMU-47. HARNESSING ZIKA VIRUS (ZIKV) ONCOLYTIC ACTIVITY IN BRAIN TUMORS

Arijita Jash, Jennifer Govero, Pei-Yong Shi, Jeremy Rich, Michael S Diamond and Milan G Chheda.

in Neuro-Oncology

November 2018; p ublished online November 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Glioblastoma (GBM) is a highly lethal immunosuppressive brain cancer that contains glioblastoma stem-like cells (GSCs). GSCs are at least partly...

ET-46ONCOLYTIC VIRAL THERAPY FOR MALIGNANT GLIOMAS USING MYXOMA VIRUS DELETED FOR ANTI-APOPTOTIC M11L GENE

Alexandra Pisklakova, Brienne McKenzie, Rajappa Kenchappa, Grant McFadden and Peter Forsyth.

in Neuro-Oncology

November 2014; p ublished online November 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Brain Tumour Initiating Cells (BTICs) are stem-like cells hypothesized to mediate recurrence in high-grade gliomas. Myxoma virus (MyxV) is a promising oncolytic virus, which is highly...

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EXTH-53. IN VIVO QUANTITATIVE ANALYSIS OF ONCOLYTIC VIRUS-TUMOR KINETICS

Hirotaka Ito, Hiroshi Nakashima, Eric McLaughlin and E Antonio Chiocca.

in Neuro-Oncology

November 2018; p ublished online November 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Oncolytic virus (OV) immunotherapy is becoming a clinically feasible therapy for cancer, with one FDA-approved product and many more in the clinical...

ET-27REPLICATION AND SPREAD OF ONCOLYTIC HERPES VIRUS IN GLIOMA STEM CELLS CAN BE ENHANCED BY SPECIFIC INHIBITION OF HISTONE DEACETYLASE 6

Johanna K. Kaufmann, Hiroshi Nakashima, Tran Nguyen, Pin-Yi Wang, Ichiro Nakano, Timothy P. Cripe and E. Antonio Chiocca.

in Neuro-Oncology

November 2014; p ublished online November 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

High-grade gliomas remain clinically challenging and under current therapies the prognosis is generally dismal. Intratumoral heterogeneity, therapy resistance, and tumor recurrence likely...

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NT-18PHASE I CLINICAL TRIAL OF ONCOLYTIC VIRUS DELTA-24-RGD (DNX-2401) WITH BIOLOGICAL ENDPOINTS: IMPLICATIONS FOR VIRO-IMMUNOTHERAPY

Frederick F. Lang, Charles Conrad, Cande Gomez-Manzano, Frank Tufaro, Raymond Sawaya, Jeffrey Weinberg, Sujit Prabhu, Gregory Fuller, Kenneth Aldape and Juan Fueyo.

in Neuro-Oncology

November 2014; p ublished online November 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Delta-24-RGD is a novel replication-competent, tumor-selective, oncolytic adenovirus with enhanced infectivity. Based on promising preclinical studies, we undertook a first-in-human Phase I...

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ET-21COMBINATION OF INTRAVENOUS AND INTRACEREBRAL INJECTION OF ONCOLYTIC PARVOVIRUS H-1 IN A PHASE I/IIA CLINICAL TRIAL OF PATIENTS WITH RECURRENT GLIOBLASTOMA MULTIFORME: PENETRATION OF H-1 VIRUS ACROSS THE BLOOD-BRAIN BARRIER

Karsten Geletneky, Assia Angelova, Barbara Leuchs, Rauf Bhat, Alexandra Just, David Capper, Ottheinz Krebs, Michael Dahm, Bernard Huber, Andreas Unterberg, Jacek Hajda and Jean Rommelaere.

in Neuro-Oncology

November 2014; p ublished online November 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

A promising alternative strategy for the treatment of glioblastoma multiforme (GBM) is the use of oncolytic viruses (OVs) that specifically replicate in and destroy tumor cells. In addition...

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TMOD-12. AN ONCOLYTIC MEASLES VIRUS SENSITIVE GROUP 3 MEDULLOBLASTOMA MODEL IN IMMUNE-COMPETENT MICE

Sangeet Lal and Corey Raffel.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Modified measles virus (MV) has demonstrated oncolytic efficacy in xenograft models of multiple tumor types using human cells in immune-deficient...

Oncolytic measles virus prolongs survival in a murine model of cerebral spinal fluid–disseminated medulloblastoma

Adam W. Studebaker, Brian Hutzen, Christopher R. Pierson, Stephen J. Russell, Evanthia Galanis and Corey Raffel.

in Neuro-Oncology

April 2012; p ublished online February 2012 .

Journal Article. Subjects: Medical Oncology; Neurology. 6352 words.

Medulloblastoma is the most common malignant brain tumor of childhood. Although the survival rate of afflicted children has improved considerably over the past several years, a subset of...

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SCDT-26. STEM CELL LOADED ONCOLYTIC VIRUSES TRACK AND KILL METASTATIC BRAIN TUMORS

Khalid Shah, Wanlu Du and David Fisher.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Brain metastatic patients have multiple metastatic lesions or diagnostically challenging asymptomatic lesions, making surgery an inadequate...

An oncolytic measles virus–sensitive Group 3 medulloblastoma model in immune-competent mice

Sangeet Lal, Diego Carrera, Joanna J Phillips, William A Weiss and Corey Raffel.

in Neuro-Oncology

November 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 6187 words.

Abstract

Background

Oncolytic measles virus (MV) is effective in xenograft models of many tumor types in...

A new patient-derived orthotopic malignant meningioma model treated with oncolytic herpes simplex virus

Fares Nigim, Shin-ichi Esaki, Michael Hood, Nina Lelic, Marianne F. James, Vijaya Ramesh, Anat Stemmer-Rachamimov, Daniel P. Cahill, Priscilla K. Brastianos, Samuel D. Rabkin, Robert L. Martuza and Hiroaki Wakimoto.

in Neuro-Oncology

September 2016; p ublished online March 2016 .

Journal Article. Subjects: Medical Oncology; Neurology. 6257 words.

Background

Higher-grade meningiomas (HGMs; World Health Organization grades II and III) pose a clinical problem due to high recurrence rates and the absence...

EXTH-20. HISTONE DEACETYLASE INHIBITOR ENHANCES ONCOLYTIC HERPES SIMPLEX VIRUS THERAPY FOR MALIGNANT MENINGIOMA

Lingyang Hua, Alessandra Gartner, Juri Kiyokawa, Samuel Rabkin, Robert Martuza and Hiroaki Wakimoto.

in Neuro-Oncology

November 2018; p ublished online November 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Malignant (anaplastic) meningioma is a minor subset of meningioma that is lethal with no effective treatment options currently. Oncolytic herpes...

EXTH-01. ZIKA VIRUS TARGETING OF MALIGNANT HUMAN AND MURINE BRAIN TUMORS

Maple Shiao, Craig Bierle, Matthew Chrostek, Andrew Crane, Georgette Danczyk, Zach Miller, Clairice Pearce, Kyle Schaible, Mark Schleiss, Christopher Sipe, Elizabeth Straub, Nikolas Toman, Shivanshi Vaid, Joseph Voth and Walter Low.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Previous studies have demonstrated that the tropism of Zika virus (ZIKV) for human neural stem cells (NSCs) leads to severe brain malformations. The...

Treatment of orthotopic malignant peripheral nerve sheath tumors with oncolytic herpes simplex virus

Slawomir Antoszczyk, Melanie Spyra, Victor Felix Mautner, Andreas Kurtz, Anat O. Stemmer-Rachamimov, Robert L. Martuza and Samuel D. Rabkin.

in Neuro-Oncology

August 2014; p ublished online January 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 5908 words.

Backgrounds

Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive and often lethal sarcoma that frequently develops in patients with...