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MCAD

Overview page. Subjects: Chemistry.

abbr. for medium chain acyl‐CoA dehydrogenase; see beta‐oxidation system.

See overview in Oxford Index

MCAD

Overview page. Subjects: Chemistry.

abbr. for medium chain acyl‐CoA dehydrogenase; see beta‐oxidation system.

See overview in Oxford Index

MCAD

Burt Vance.

in A Dictionary of Abbreviations

P ublished online January 2011 .

Reference Entry. 5 words.

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MCAD

Edited by Richard Cammack, Teresa Atwood, Peter Campbell, Howard Parish, Anthony Smith, Frank Vella and John Stirling.

in Oxford Dictionary of Biochemistry and Molecular Biology

January 2006; p ublished online January 2008 .

Reference Entry. Subjects: Biochemistry. 10 words.

abbr. for medium chain acyl‐CoA dehydrogenase; see beta‐oxidation system.

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Preimplantation genetic diagnosis for medium-chain acyl-CoA dehydrogenase (MCAD) deficiency

K. Sermon, P. Henderix, W. Lissens, A.De Vos, M. Vandervorst, A. Vanderfaeillie, E. Vamos, A.Van Steirteghem and I. Liebaers.

in MHR: Basic science of reproductive medicine

December 2000; p ublished online December 2000 .

Journal Article. Subjects: Reproductive Medicine. 3054 words.

Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is the most common defect in fatty acid oxidation. The disease is inherited in an autosomal recessive fashion (carrier frequency around...

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The Molecular Basis of Medium-Chain Acyl-CoA Dehydrogenase (MCAD) Deficiency in Compound Heterozygous Patients: Is There Correlation between Genotype and Phenotype?

Brage Storstein Andresen, Peter Bross, Szabolcs Udvari, Jean Kirk, George Gray, Stanislav Kmoch, Nestor Chamoles, Inga Knudsen, Vibeke Winter, Bridget Wilcken, Ichiro Yokota, Kimberly Hart, Seymour Packman, Jean Paul Harpey, Jean Marie Saudubray, Daniel E. Hale, Lars Bolund, Steen Kølvraa and Niels Gregersen.

in Human Molecular Genetics

May 1997; p ublished online May 1997 .

Journal Article. Subjects: Genetics and Genomics. 9675 words.

Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is the most commonly recognized defect of mitochondrial β-oxidation. It is potentially fatal, but shows a wide clinical spectrum. The...

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PGC-1β Down-Regulation Is Associated With Reduced ERRα Activity and MCAD Expression in Skeletal Muscle of Senescence-Accelerated Mice

Ricardo Rodríguez-Calvo, Mireia Jové, Teresa Coll, Antoni Camins, Rosa M. Sánchez, Marta Alegret, Manuel Merlos, Mercè Pallàs, Juan C. Laguna and Manuel Vázquez-Carrera.

in The Journals of Gerontology: Series A

August 2006; p ublished online August 2006 .

Journal Article. Subjects: Geriatric Medicine; Biological Sciences. 4858 words.

Mitochondrial dysfunction is involved in the development of aging. Here, we examined the effect of aging on the skeletal muscle expression of two isoforms of the transcriptional peroxisome...

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FT-IR Spectroscopic Studies on the Molecular Mechanism for Substrate Specificity/Activation of Medium-Chain Acyl-CoA Dehydrogenase

Yasuzo Nishina, Kyosuke Sato, Haruhiko Tamaoki, Chiaki Setoyama, Retsu Miura and Kiyoshi Shiga.

in The Journal of Biochemistry

September 2009; p ublished online May 2009 .

Journal Article. Subjects: Biochemistry. 4227 words.

The interactions of acyl-CoA with medium-chain acyl-CoA dehydrogenases (MCADs) reconstituted with artificial FADs—i.e. 8-CN-, 7,8-Cl2-, 8-Cl-, 8-OCH3- and 8-NH2-FAD—were investigated by...

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Three-Dimensional Structure of the Flavoenzyme Acyl-CoA Oxidase-II from Rat Liver, the Peroxisomal Counterpart of Mitochondrial Acyl-CoA Dehydrogenase

Yoshitaka Nakajima, Ikuko Miyahara, Ken Hirotsu, Yasuzo Nishina, Kiyoshi Shiga, Chiaki Setoyama, Haruhiko Tamaoki and Retsu Miura.

in The Journal of Biochemistry

March 2002; p ublished online March 2002 .

Journal Article. Subjects: Biochemistry. 0 words.

Acyl-CoA oxidase (ACO) catalyzes the first and rate-determining step of the peroxisomal β-oxidation of fatty acids. The crystal structure of ACO-II, which is one of two forms of rat liver...

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<sup>13</sup>C-NMR Study on the Interaction of Medium-Chain Acyl-CoA Dehydrogenase with Acetoacetyl-CoA

Retsu Miura, Yasuzo Nishina, Shigeru Fujii and Kiyoshi Shiga.

in The Journal of Biochemistry

March 1996; p ublished online March 1996 .

Journal Article. Subjects: Biochemistry. 0 words.

The charge-transfer interaction in the complex of pig kidney medium-chain acyl-CoA dehydrogenase (MCAD) with acetoacetyl-CoA was investigated by 13C-NMR spectroscopy and molecular orbital...

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Mechanism for the Recognition and Activation of Substrate in Medium-Chain Acyl-CoA Dehydrogenase

Haruhiko Tamaoki, Yasuzo Nishina, Kiyoshi Shiga and Retsu Miura.

in The Journal of Biochemistry

February 1999; p ublished online February 1999 .

Journal Article. Subjects: Biochemistry. 0 words.

The mechanism underlying the recognition and activation of the substrate for medium-chain acyl-CoA dehydrogenase (MCAD) was spectroscopically investigated using 3-thia-acyl-CoAs as...

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Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failure

Julie H. Rennison, Tracy A. McElfresh, Isidore C. Okere, Hiral V. Patel, Amy B. Foster, Kalpana K. Patel, Maria S. Stoll, Paul E. Minkler, Hisashi Fujioka, Brian D. Hoit, Martin E. Young, Charles L. Hoppel and Margaret P. Chandler.

in Cardiovascular Research

July 2008; p ublished online March 2008 .

Journal Article. Subjects: Cardiovascular Medicine. 6218 words.

Aims

Heart failure is associated with decreased myocardial fatty acid oxidation capacity and has been likened to energy starvation. Increased fatty acid...

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A potential link between peroxisome proliferator-activated receptor signalling and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy

Fatima Djouadi, Yves Lecarpentier, Jean-Louis Hébert, Philippe Charron, Jean Bastin and Catherine Coirault.

in Cardiovascular Research

October 2009; p ublished online June 2009 .

Journal Article. Subjects: Cardiovascular Medicine. 4079 words.

Aims

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by major fibro-fatty replacement of the right ventricle (RV). We hypothesized...

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Dissociation between gene and protein expression of metabolic enzymes in a rodent model of heart failure

Eric E. Morgan, Margaret P. Chandler, Martin E. Young, Tracy A. McElfresh, Theodore A. Kung, Julie H. Rennison, Kou-Yi Tserng, Brian D. Hoit and William C. Stanley.

in European Journal of Heart Failure

November 2006; p ublished online November 2006 .

Journal Article. Subjects: Cardiovascular Medicine. 3701 words.

Studies in advanced heart failure show down-regulation of fatty acid oxidation genes, possibly due to decreased expression of the nuclear transcription factors peroxisome proliferator...

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Molecular Mechanism of the Drop in the p<i>K</i> <sub>a</sub> of a Substrate Analog Bound to Medium-Chain Acyl-CoA Dehydrogenase: Implications for Substrate Activation

Yasuzo Nishina, Kyosuke Sato, Haruhiko Tamaoki, Takeyuki Tanaka, Chiaki Setoyama, Retsu Miura and Kiyoshi Shiga.

in The Journal of Biochemistry

December 2003; p ublished online December 2003 .

Journal Article. Subjects: Biochemistry. 5539 words.

The pK a value of a substrate analogue 3-thiaoctanoyl-CoA at αC-H is known to drop from ca. 16 in the free state to 5–6 upon binding to medium-chain acyl-CoA dehydrogenase...

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Postinfarction heart failure in rats is associated with upregulation of GLUT-1 and downregulation of genes of fatty acid metabolism

Nathalie Rosenblatt-Velin, Christophe Montessuit, Irène Papageorgiou, Jérôme Terrand and René Lerch.

in Cardiovascular Research

December 2001; p ublished online December 2001 .

Journal Article. Subjects: Cardiovascular Medicine. 5668 words.

Abstract

Objectives: Increasing evidence suggests that left ventricular remodeling is associated with a shift from fatty acid to glucose...

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Look-alike/smell-alike perfumes fall foul of trade mark and comparative advertising laws

Joel Smith and Rachel Montagnon.

in Journal of Intellectual Property Law & Practice

October 2009; p ublished online August 2009 .

Journal Article. Subjects: Arbitration; Intellectual Property Law. 1277 words.

In a reference from the Court of Appeal for England and Wales, the ECJ held that trade mark infringement can occur where there has been ‘free-riding’ on another brand's image and associated...

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Synthesis and cell-free cloning of DNA libraries using programmable microfluidics

Tuval Ben Yehezkel, Arnaud Rival, Ofir Raz, Rafael Cohen, Zipora Marx, Miguel Camara, Jean-Frédéric Dubern, Birgit Koch, Stephan Heeb, Natalio Krasnogor, Cyril Delattre and Ehud Shapiro.

in Nucleic Acids Research

February 2016; p ublished online October 2015 .

Journal Article. Subjects: Research Methods in Life Sciences. 9198 words.

Microfluidics may revolutionize our ability to write synthetic DNA by addressing several fundamental limitations associated with generating novel genetic constructs. Here we report the...

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Lack of NF-κB1 (p105/p50) attenuates unloading-induced downregulation of PPARα and PPARα-regulated gene expression in rodent heart

Peter Razeghi, Mou-Er Wang, Keith A. Youker, Leonard Golfman, Stanislaw Stepkowski and Heinrich Taegtmeyer.

in Cardiovascular Research

April 2007; p ublished online April 2007 .

Journal Article. Subjects: Cardiovascular Medicine. 2932 words.

Abstract

Objective: Unloading of the rodent heart activates the fetal gene program, decreases peroxisome proliferator-activated receptor α...

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A systematic review of evidence for the appropriateness of neonatal screening programmes for inborn errors of metabolism

Margaret J. Thomason, Joanne Lord, Murray D. Bain, Ronald A. Chalmers, Peter Littlejohns, G. Michael Addison, A. Hervey Wilcox and Carol A. Seymour.

in Journal of Public Health

September 1998; p ublished online September 1998 .

Journal Article. Subjects: Public Health and Epidemiology. 0 words.

Background

Developments in screening technology and increased understanding of the natural history and treatment of inborn errors of metabolism (IEMs) have...

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Intramolecular and Intermolecular Perturbation on Electronic State of FAD Free in Solution and Bound to Flavoproteins: FTIR Spectroscopic Study by Using the C = O Stretching Vibrations as Probes

Yasuzo Nishina, Kyosuke Sato, Chiaki Setoyama, Haruhiko Tamaoki, Retsu Miura and Kiyoshi Shiga.

in The Journal of Biochemistry

August 2007; p ublished online August 2007 .

Journal Article. Subjects: Biochemistry. 4800 words.

The intramolecular and intermolecular perturbation on the electronic state of FAD was investigated by FTIR spectroscopy by using the C=O stretching vibrations as probes in D2O solution....

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