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poly(C)

Overview page. Subjects: Chemistry.

abbr. for polycytidylate.

See overview in Oxford Index

Synthesis of novel poly(dG)–poly(dG)–poly(dC) triplex structure by Klenow exo fragment of DNA polymerase I

Alexander Kotlyar, Natalia Borovok, Tatiana Molotsky, Dmitry Klinov, Benjamin Dwir and Eli Kapon.

in Nucleic Acids Research

December 2005; p ublished online December 2005 .

Journal Article. Subjects: Molecular and Cell Biology. 5213 words.

The extension of the G-strand of long (700 bp) poly(dG)–poly(dC) by the Klenow exo fragment of DNA polymerase I yields a complete triplex structure of the H-DNA type. High-performance...

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Dehydration, deamination and enzymatic repair of cytosine glycols from oxidized poly(dG-dC) and poly(dI-dC)

Sébastien Tremblay and J. Richard Wagner.

in Nucleic Acids Research

January 2008; p ublished online November 2007 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6757 words.

Cytosine glycols (5,6-dihydroxy-5,6-dihydrocytosine) are initial products of cytosine oxidation. Because these products are not stable, virtually all biological studies have focused on the...

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Cationic Liposome-Mediated Efficient Induction of Type I Interferons by a Low Dose of Poly I: Poly C in Mouse Cell Lines

Sachiko Okamoto, Yoshihiko Watanabe, Yoshinobu Takakura and Mitsuru Hashida.

in The Journal of Biochemistry

October 1998; p ublished online October 1998 .

Journal Article. Subjects: Biochemistry. 0 words.

Double-stranded polyriboinosinic acid:polyribocytidylic acid (poly I:poly C) is a powerful inducer of type I interferons (IFNs). However, the dose of poly I:poly C required for efficient...

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In vitro synthesis of uniform poly(dG)–poly(dC) by Klenow exo fragment of polymerase I

Alexander B. Kotlyar, Natalia Borovok, Tatiana Molotsky, Ludmila Fadeev and Michael Gozin.

in Nucleic Acids Research

January 2005; p ublished online January 2005 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 8704 words.

In this paper, we describe a production procedure of the one-to-one double helical complex of poly(dG)–poly(dC), characterized by a well-defined length (up to 10 kb) and narrow size...

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Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL‐12

Redouane Rouas, Philippe Lewalle, Frank El Ouriaghli, Berengere Nowak, Hughes Duvillier and Philippe Martiat.

in International Immunology

May 2004; p ublished online May 2004 .

Journal Article. Subjects: Immunology; Biological Sciences. 4574 words.

Dendritic cells (DC) are professional antigen‐presenting cells that play a central role in the control of immunity. Mature DC are characterized by high expression levels of MHC and...

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Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation

Kohsuke Kanekura, Takuya Yagi, Alexander J. Cammack, Jana Mahadevan, Masahiko Kuroda, Matthew B. Harms, Timothy M. Miller and Fumihiko Urano.

in Human Molecular Genetics

May 2016; p ublished online February 2016 .

Journal Article. Subjects: Genetics and Genomics. 6191 words.

The expansion of the GGGGCC hexanucleotide repeat in the non-coding region of the Chromosome 9 open-reading frame 72 (C9orf72) gene is the most common genetic cause of frontotemporal...

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P618PAR2 expression differentially regulates immune response upon treatment with Poly(I:C) and LPS

A Weithaeuser, HP Schultheiss and U Rauch.

in Cardiovascular Research

July 2014; p ublished online July 2014 .

Journal Article. Subjects: Cardiovascular Medicine. 0 words.

Introduction: The protease activated receptor 2 (PAR2) is a G-protein coupled receptor, that is activated by serine proteases such as trypsin, tryptase and the complex composed...

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C9ORF72 dipeptide repeat poly-GA inclusions promote intracellular aggregation of phosphorylated TDP-43

Takashi Nonaka, Masami Masuda-Suzukake, Masato Hosokawa, Aki Shimozawa, Shinobu Hirai, Haruo Okado and Masato Hasegawa.

in Human Molecular Genetics

August 2018; p ublished online May 2018 .

Journal Article. Subjects: Genetics and Genomics. 6065 words.

Abstract

Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are neurodegenerative diseases characterized by accumulation of insoluble...

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Structure and RNA binding of the third KH domain of poly(C)-binding protein 1

M. Sidiqi, J. A. Wilce, J. P. Vivian, C. J. Porter, A. Barker, P. J. Leedman and M. C. J. Wilce.

in Nucleic Acids Research

February 2005; p ublished online February 2005 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6513 words.

Poly(C)-binding proteins (CPs) are important regulators of mRNA stability and translational regulation. They recognize C-rich RNA through their triple KH (hn RNP K homology) domain...

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Microglia isolated from patients with glioma gain antitumor activities on poly (I:C) stimulation

Tim Kees, Jennifer Lohr, Johannes Noack, Rodrigo Mora, Georg Gdynia, Grischa Tödt, Aurélie Ernst, Bernhard Radlwimmer, Christine S. Falk, Christel Herold-Mende and Anne Régnier-Vigouroux.

in Neuro-Oncology

January 2012; p ublished online October 2011 .

Journal Article. Subjects: Medical Oncology; Neurology. 6820 words.

The role of microglia, the brain-resident macrophages, in glioma biology is still a matter of debate. Clinical observations and in vitro studies in the mouse model indicate that microglia...

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A novel role for poly(C) binding proteins in programmed ribosomal frameshifting

Sawsan Napthine, Emmely E. Treffers, Susanne Bell, Ian Goodfellow, Ying Fang, Andrew E. Firth, Eric J. Snijder and Ian Brierley.

in Nucleic Acids Research

July 2016; p ublished online June 2016 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 8484 words.

Translational control through programmed ribosomal frameshifting (PRF) is exploited widely by viruses and increasingly documented in cellular genes. Frameshifting is induced by mRNA...

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Antiviral responses of human Leydig cells to mumps virus infection or poly I:C stimulation

A. Le Tortorec, H. Denis, A-P. Satie, J-J. Patard, A. Ruffault, B. Jégou and N. Dejucq-Rainsford.

in Human Reproduction

September 2008; p ublished online June 2008 .

Journal Article. Subjects: Reproductive Medicine. 6562 words.

BACKGROUND

The immuno-privileged status of the testis is essential to the maintenance of its functions, and innate immunity is likely to play a key role in...

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A new xeroderma pigmentosum group C poly(AT) insertion/deletion polymorphism

Sikandar G. Khan, E.Jeffrey Metter, Robert E. Tarone, Vilhelm A. Bohr, Lawrence Grossman, Mohammad Hedayati, Sherri J. Bale, Steffen Emmert and Kenneth H. Kraemer.

in Carcinogenesis

October 2000; p ublished online October 2000 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 5235 words.

We found a common biallelic polymorphism (PAT) in the xeroderma pigmentosum complementation group C (XPC) DNA repair gene consisting of an insertion of 83 bases of A and T [poly(AT)] and a 5...

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poly(C)

Overview page. Subjects: Chemistry.

abbr. for polycytidylate.

See overview in Oxford Index

poly(C)

Edited by Richard Cammack, Teresa Atwood, Peter Campbell, Howard Parish, Anthony Smith, Frank Vella and John Stirling.

in Oxford Dictionary of Biochemistry and Molecular Biology

January 2006; p ublished online January 2008 .

Reference Entry. Subjects: Biochemistry. 4 words.

abbr. for polycytidylate.

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Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides

Yano M. K. Yoga, Daouda A. K. Traore, Mahjooba Sidiqi, Chris Szeto, Nicole R. Pendini, Andrew Barker, Peter J. Leedman, Jacqueline A. Wilce and Matthew C. J. Wilce.

in Nucleic Acids Research

June 2012; p ublished online February 2012 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 9811 words.

Poly-C-binding proteins are triple KH (hnRNP K homology) domain proteins with specificity for single stranded C-rich RNA and DNA. They play diverse roles in the regulation of protein...

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Poly(A) binding protein, C-terminally truncated by the hepatitis A virus proteinase 3C, inhibits viral translation

Bo Zhang, Graziella Morace, Verena Gauss-Müller and Yuri Kusov.

in Nucleic Acids Research

September 2007; p ublished online August 2007 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 7336 words.

Proteolytic cleavage of translation initiation factors is a means to interfere with mRNA circularization and to induce translation arrest during picornaviral replication or apoptosis. It...

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Poly(I:C)-Induced Protection of Neonatal Mice Against Intestinal Cryptosporidium parvum Infection Requires an Additional TLR5 Signal Provided by the Gut Flora

Louis Lantier, Françoise Drouet, William Guesdon, Roselyne Mancassola, Coralie Metton, Richard Lo-Man, Catherine Werts, Fabrice Laurent and Sonia Lacroix-Lamandé.

in The Journal of Infectious Diseases

February 2014; p ublished online September 2013 .

Journal Article. Subjects: Infectious Diseases; Immunology; Public Health and Epidemiology; Microbiology. 5458 words.

The neonatal intestinal immune system is still undergoing development at birth, leading to a higher susceptibility to mucosal infections. In this study, we investigated the effect of...

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Fast repair of the radical cations of dCMP and poly C by quercetin and rutin

Chenyang Zhao, Yimin Shi, Weizheng Lin, Wengfeng Wang, Zhongjian Jia, Side Yao, Botao Fan and Rongliang Zheng.

in Mutagenesis

May 2001; p ublished online May 2001 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Genetics and Genomics. 3517 words.

The effects of quercetin and rutin on the repair of the radical cations of dCMP and poly C were studied using the technique of pulse radiolysis. The radical cations of dCMP and poly C were...

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Dynamic accumulation and degradation of poly(3-hydroxyalkanoate)s in living cells of Azotobacter vinelandii UWD characterized by 13C NMR

Yong-Bin Yan, Qiong Wu and Ri-Qing Zhang.

in FEMS Microbiology Letters

December 2000; p ublished online January 2006 .

Journal Article. 2164 words.

Abstract

The synthesis and degradation of poly(3-hydroxybutyrate) (PHB) and poly(3-hydroxybutyrate-co-hydroxyvalerate) (P(HB-co-HV)) by Azotobacter vinelandiinull...

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