Book

Severe Depression

Roger McIntyre [[missing key: and]] Jay Nathanson

Published on behalf of Oxford University Press

Published in print February 2010 | ISBN: 9780199570249
Published online May 2011 | e-ISBN: 9780191740350 | DOI: https://dx.doi.org/10.1093/med/9780199570249.001.0001

Series: Oxford Psychiatry Library

Severe Depression

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Defining severe depression

Roger S. McIntyre and Jay Nathanson.

in Severe Depression

February 2010; p ublished online May 2011 .

Chapter. Subjects: Psychiatry. 2689 words.

Currently, no consensually agreed-upon definition of “severe depression” exists

HAMD-17 and MADRS scores of 28–30 and 30+,...

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Epidemiology and burden of depression

Roger S. McIntyre and Jay Nathanson.

in Severe Depression

February 2010; p ublished online May 2011 .

Chapter. Subjects: Psychiatry. 935 words.

Major depressive disorder is the leading cause of disability worldwide among young adults

Severe phenotypes of depression...

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Introduction

Roger S. McIntyre and Jay Nathanson.

in Severe Depression

February 2010; p ublished online May 2011 .

Chapter. Subjects: Psychiatry. 621 words.

This introductory chapter focuses on major depressive disorder (MDD. The causes of MDD are multifactorial, and include a modest genetic underpinning as well as exposure to distal (e.g.,...

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Medical comorbidity

Roger S. McIntyre and Jay Nathanson.

in Severe Depression

February 2010; p ublished online May 2011 .

Chapter. Subjects: Psychiatry. 992 words.

Individuals with major depressive disorder are differentially affected by stress-sensitive chronic medical disability

Shared...

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Neurobiology of depression

Roger S. McIntyre and Jay Nathanson.

in Severe Depression

February 2010; p ublished online May 2011 .

Chapter. Subjects: Psychiatry. 5702 words.

There are three major networks associated with the pathophysiology (and possibly treatment) of MDD: the immunoinflammatory network, the metabolic network...

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Neuromodulation

Roger S. McIntyre and Jay Nathanson.

in Severe Depression

February 2010; p ublished online May 2011 .

Chapter. Subjects: Psychiatry. 2860 words.

Neuromodulatory approaches include deep brain stimulation (DBS), vagus nerve stimulation (VNS), transcranial magnetic stimulation (TMS), and...

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Pharmacological approaches to depression

Roger S. McIntyre and Jay Nathanson.

in Severe Depression

February 2010; p ublished online May 2011 .

Chapter. Subjects: Psychiatry. 4211 words.

Tricyclic antidepressants have been the conventional standard of efficacy in severe depression

Conventional pharmacotherapy...

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Pharmacological augmentation strategies for depression

Roger S. McIntyre and Jay Nathanson.

in Severe Depression

February 2010; p ublished online May 2011 .

Chapter. Subjects: Psychiatry. 1779 words.

The best proven augmentation strategy in MDD is with the use of second-generation antipsychotics (SGAs, “atypicals”)

Several...

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Psychotherapy

Roger S. McIntyre and Jay Nathanson.

in Severe Depression

February 2010; p ublished online May 2011 .

Chapter. Subjects: Psychiatry. 1690 words.

Relatively few studies evaluating the use of manual-based psychotherapy (e.g., cognitive-behavioural therapy) in severe MDD exist

null...

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Self-help resources

Roger S. McIntyre and Jay Nathanson.

in Severe Depression

February 2010; p ublished online May 2011 .

Chapter. Subjects: Psychiatry. 115 words.

This chapter lists a variety of websites which can be used to get more information on depression or mental health in the UK, Canada, or the United States.

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Suicidality

Roger S. McIntyre and Jay Nathanson.

in Severe Depression

February 2010; p ublished online May 2011 .

Chapter. Subjects: Psychiatry. 656 words.

The term “suicidality” is highly ambiguous and of questionable clinical utility; practitioners need to disaggregate “suicidality” into transient suicidal...

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