Journal

Toxicological Sciences

ISSN: 1096-6080
e-ISSN: 1096-0929 | DOI: https://dx.doi.org/10.1093/toxsci
Toxicological Sciences

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A 21st Century Paradigm for Evaluating the Health Hazards of Nanoscale Materials?

Nigel J. Walker and John R. Bucher.

in Toxicological Sciences

August 2009; p ublished online May 2009 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 2385 words.

Over the past 5 years we have seen an increase in the attention focused on the assessment of the potential health risk posed by nanoscale materials. The diversity of these materials with...

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A 28-Day Oral Dose Toxicity Study Enhanced to Detect Endocrine Effects of Hexabromocyclododecane in Wistar Rats

Leo T. M. van der Ven, Aart Verhoef, Ton van de Kuil, Wout Slob, Pim E. G. Leonards, Theo J. Visser, Timo Hamers, Maria Herlin, Helen Håkansson, Hanna Olausson, Aldert H. Piersma and Josephus G. Vos.

in Toxicological Sciences

December 2006; p ublished online September 2006 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8809 words.

A 28-day repeated dose study in rats (OECD407) enhanced for endocrine and immune parameters was performed with hexabromocyclododecane (HBCD). Rats were exposed by daily gavage to HBCD...

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A 2-Year Comparison Study of Crl:CD BR and Hsd:Sprague-Dawley SD Rats

JOHN C. PETTERSEN, ROBERT L. MORRISSEY, DONALD R. SAUNDERS, KENNETH L. PAVKOV, LOUIS G. LUEMPERT, JOHN C. TURNIER, DALE W. MATHESON and DANIEL R. SCHWARTZ.

in Toxicological Sciences

October 1996; p ublished online October 1996 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

In this 2-year study, the suitability of the Hsd:Sprague-Dawley SD (SD) as a replacement for the Crl:CD BR (CD) rat was assessed by comparing survival rates, palpable mass incidence, body...

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A 3D Human Airway Model Enables Prediction of Respiratory Toxicity of Inhaled Drugs In Vitro

Kinga Balogh Sivars, Ulf Sivars, Ellinor Hornberg, Hui Zhang, Lena Brändén, Rosy Bonfante, Song Huang, Samuel Constant, Ian Robinson, Catherine J Betts and Per M Åberg.

in Toxicological Sciences

March 2018; p ublished online November 2017 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 5401 words.

Abstract

Respiratory tract toxicity represents a significant cause of attrition of inhaled drug candidates targeting respiratory diseases. One of the key...

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A 90-Day Chloroform Inhalation Study in F-344 Rats: Profile of Toxicity and Relevance to Cancer Studies

MICHAEL V. TEMPLIN, JEFFREY L. LARSON, BYRON E. BUTTERWORTH, KEITH C. JAMISON, JOEL R. LEININGER, STEPHANE MERY, KEVIN T. MORGAN, BRIAN A. WONG and DOUGLAS C. WOLF.

in Toxicological Sciences

July 1996; p ublished online July 1996 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

Composition of diet may influence growth, diseases, tumor rates, and responses to chemical treatment. Since 1980 the NIH–07 open formula nonpurified diet has been the selected diet for the...

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A 90-Day Chloroform Inhalation Study in Female and Male B6C3F1 Mice: Implications for Cancer Risk Assessment

JEFFREY L. LARSON, MICHAEL V. TEMPLIN, DOUGLAS C. WOLF, KEITH C. JAMISON, JOEL R. LEINNINGER, STEPHANE MÈRY, KEVIN T. MORGAN, BRAIN A. WONG, RORY B. CONOLLY and BYRON E. BUTTERWORTH.

in Toxicological Sciences

March 1996; p ublished online March 1996 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

High doses of chloroform induced liver cancer in male and female B6C3F1 mice when administered by gavage, kidney cancer in male Osborne-Mendel rats when given by gavage or in the drinking...

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A 90-Day Drinking Water Toxicity Study in Rats of the Environmental Contaminant Ammonium Perchlorate

Joseph C. Siglin, David R. Mattie, Darol E. Dodd, Paul K. Hildebrandt and William H. Baker.

in Toxicological Sciences

September 2000; p ublished online September 2000 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 9519 words.

Perchlorate (ClO 4), the dissociated anion of perchlorate salts such as ammonium, potassium, and sodium perchlorate, has been recently recognized as a persistent and pervasive...

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A 90-Day Toxicological Evaluation of Compound 1080 (Sodium Monofluoroacetate) in Sprague-Dawley Rats

Charles T. Eason and Patricia Turck.

in Toxicological Sciences

October 2002; p ublished online October 2002 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7262 words.

Groups of Sprague-Dawley rats received sodium monofluoroacetate (Compound 1080) at 0.025, 0.075, and 0.25 mg/kg by oral gavage once daily for 90 days and were then euthanized. The control...

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ABCB1 Protects Kidney Proximal Tubule Cells Against Cadmium-Induced Apoptosis: Roles of Cadmium and Ceramide Transport

Wing-Kee Lee, Blazej Torchalski, Naschla Kohistani and Frank Thévenod.

in Toxicological Sciences

June 2011; p ublished online March 2011 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6754 words.

Cadmium (Cd2+) damages the kidney proximal tubule (PT) by ceramide-dependent apoptosis and is also a class I carcinogen. Multidrug resistance P-glycoprotein (MDR1, ABCB1) confers resistance...

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Aberrant Adult Neurogenesis in the Subventricular Zone-Rostral Migratory Stream-Olfactory Bulb System Following Subchronic Manganese Exposure

Sherleen Fu, Wendy Jiang, Xiang Gao, Andrew Zeng, Daniel Cholger, Jason Cannon, Jinhui Chen and Wei Zheng.

in Toxicological Sciences

April 2016; p ublished online January 2016 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 10873 words.

Adult neurogenesis occurs in brain subventricular zone (SVZ). Our recent data reveal an elevated proliferation of BrdU(+) cells in SVZ following subchronic manganese (Mn) exposure in rats....

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Aberrant Epigenetic Gene Regulation in GABAergic Interneuron Subpopulations in the Hippocampal Dentate Gyrus of Mouse Offspring Following Developmental Exposure to Hexachlorophene

Yousuke Watanabe, Hajime Abe, Kota Nakajima, Maky Ideta-Otsuka, Katsuhide Igarashi, Gye-Hyeong Woo, Toshinori Yoshida and Makoto Shibutani.

in Toxicological Sciences

May 2018; p ublished online January 2018 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7358 words.

Abstract

Maternal hexachlorophene (HCP) exposure causes transient disruption of hippocampal neurogenesis in mouse offspring. We examined epigenetically...

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Aberrant Expression of miR-638 Contributes to Benzo(a)pyrene-Induced Human Cell Transformation

Daochuan Li, Qing Wang, Caixia Liu, Huawei Duan, Xiaowen Zeng, Bo Zhang, Xiaodong Li, Jian Zhao, Shifu Tang, Zhifang Li, Xiumei Xing, Ping Yang, Liping Chen, Junling Zeng, Xiaonian Zhu, Shixin Zhang, Zhengbao Zhang, Lu Ma, Zhini He, Erman Wang, Yongmei Xiao, Yuxin Zheng and Wen Chen.

in Toxicological Sciences

February 2012; p ublished online November 2011 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6479 words.

Identification of aberrant microRNA (miRNA) expression during chemical carcinogen–induced cell transformation will lead to a better understanding of the substantial role of miRNAs in cancer...

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Aberrant Ligand-Induced Activation of G Protein–Coupled Estrogen Receptor 1 (GPER) Results in Developmental Malformations During Vertebrate Embryogenesis

B. Sumith Jayasinghe and David C. Volz.

in Toxicological Sciences

January 2012; p ublished online October 2011 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6741 words.

G protein–coupled estrogen receptor 1 (GPER) is a G protein–coupled receptor (GPCR) unrelated to nuclear estrogen receptors but strongly activated by 17β-estradiol in both mammals and fish....

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Aberrant Methylation of Hypermethylated-in-Cancer-1 and Exocyclic DNA Adducts in Tobacco Smokers

Marco E. M. Peluso, Armelle Munnia, Valentina Bollati, Petcharin Srivatanakul, Adisorn Jedpiyawongse, Suleeporn Sangrajrang, Marcello Ceppi, Roger W. Giese, Paolo Boffetta and Andrea A. Baccarelli.

in Toxicological Sciences

January 2014; p ublished online October 2013 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6115 words.

Tobacco smoke has been shown to produce both DNA damage and epigenetic alterations. However, the potential role of DNA damage in generating epigenetic changes is largely underinvestigated...

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Aberrant microRNA Expression Likely Controls RAS Oncogene Activation During Malignant Transformation of Human Prostate Epithelial and Stem Cells by Arsenic

Ntube N. O. Ngalame, Erik J. Tokar, Rachel J. Person, Yuanyuan Xu and Michael P. Waalkes.

in Toxicological Sciences

April 2014; p ublished online January 2014 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6189 words.

Inorganic arsenic (iAs), a human carcinogen, potentially targets the prostate. iAs malignantly transforms the RWPE-1 human prostate epithelial line to CAsE-PE cells, and a derivative normal...

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Aberration in Epigenetic Gene Regulation in Hippocampal Neurogenesis by Developmental Exposure to Manganese Chloride in Mice

Liyun Wang, Ayako Shiraki, Megu Itahashi, Hirotoshi Akane, Hajime Abe, Kunitoshi Mitsumori and Makoto Shibutani.

in Toxicological Sciences

November 2013; p ublished online August 2013 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6879 words.

We have shown that maternal manganese (Mn) exposure caused sustained disruption of hippocampal neurogenesis of mouse offspring. To clarify the effects of maternal Mn exposure on epigenetic...

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Abnormal Liver Development and Resistance to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Toxicity in Mice Carrying a Mutation in the DNA-Binding Domain of the Aryl Hydrocarbon Receptor

Maureen K. Bunger, Edward Glover, Susan M. Moran, Jacqueline A. Walisser, Garet P. Lahvis, Erin L. Hsu and Christopher A. Bradfield.

in Toxicological Sciences

November 2008; p ublished online July 2008 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6068 words.

The aryl hydrocarbon receptor (AHR) is known for its role in the adaptive and toxic responses to a large number of environmental contaminants, as well as its role in hepatovascular...

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Absence of carcinogenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat

Julie Muller, Monique Delos, Nadtha Panin, Virginie Rabolli, François Huaux and Dominique Lison.

in Toxicological Sciences

August 2012; p ublished online July 2012 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 76 words.

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Absence of Carcinogenic Response to Multiwall Carbon Nanotubes in a 2-Year Bioassay in the Peritoneal Cavity of the Rat

Julie Muller, Monique Delos, Nadtha Panin, Virginie Rabolli, François Huaux and Dominique Lison.

in Toxicological Sciences

August 2009; p ublished online May 2009 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 3892 words.

Toxicological investigations of carbon nanotubes have shown that they can induce pulmonary toxicity, and similarities with asbestos fibers have been suggested. We previously reported that...

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Absence of Mutagenic Effects of Sodium Dichloroacetate

ANTHONY W. FOX, XIAOQING YANG, HEMATHALA MURLI, TIMOTHY E. LAWLOR, MARIA A. CIFONE and FREDERICK E. RENO.

in Toxicological Sciences

July 1996; p ublished online July 1996 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

Sodium dichloroacetate (DCA) is a drug with potential for treating patients with stroke and head injury. Conflicting evidence has been published on the mutagenic potential of DCA. A series...

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