Journal Article

Is there a local renin—angiotensin system in the heart?

A.H.Jan Danser, Jasper J Saris, Martin P Schuijt and Jorge P van Kats

in Cardiovascular Research

Published on behalf of European Society of Cardiology

Volume 44, issue 2, pages 252-265
Published in print November 1999 | ISSN: 0008-6363
Published online November 1999 | e-ISSN: 1755-3245 | DOI: https://dx.doi.org/10.1016/S0008-6363(99)00202-3
Is there a local renin—angiotensin system in the heart?

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Abstract

The existence of a local renin—angiotensin system in the heart is still a controversial issue. This review discusses the evidence, obtained from studies in cardiac cells, in isolated perfused hearts and in intact animals and humans, both under normal and pathological conditions, for local production of prorenin, renin, angiotensinogen, angiotensin-converting enzyme, angiotensin I and angiotensin II at cardiac tissue sites. In addition, the role of alternative angiotensin-generating enzymes (cathepsin, chymase) and the possibility of (pro)renin uptake from the circulation is evaluated.

Keywords: Angiotensin; ACE inhibitors; Interstitial space; Myocytes; Renin angiotensin system

Journal Article.  10215 words.  Illustrated.

Subjects: Cardiovascular Medicine

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