Journal Article

Healing after myocardial infarction

Georg Ertl and Stefan Frantz

in Cardiovascular Research

Published on behalf of European Society of Cardiology

Volume 66, issue 1, pages 22-32
Published in print April 2005 | ISSN: 0008-6363
Published online April 2005 | e-ISSN: 1755-3245 | DOI: https://dx.doi.org/10.1016/j.cardiores.2005.01.011
Healing after myocardial infarction

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Abstract

Wounding and healing are archaic principles, prerequisite for survival of any biologic material. However, strategies to cope with wounding may be quite different among organisms, species, or among various organs of one species. Today, myocardial infarction and the consequent loss of fully functional myocardium is the major aetiology for heart failure. Despite aggressive primary therapy, prognosis remains serious in patients with large infarction and severe left ventricular dysfunction. Thus, it would be highly desirable to influence healing of the cardiac wound to maintain structure and function of the heart. Herein, we review different, important factors of cardiac healing including reperfusion, mechanical stress, gender, and neurohormonal factors as well as specific factors essential for healing which may be genetic or acquired, emphasizing similarities and discrepancies between different organs and species.

Keywords: Myocardial infarction; Healing; Inflammation; MMP; RAAS

Journal Article.  7903 words.  Illustrated.

Subjects: Cardiovascular Medicine

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