Journal Article

Low levels of vitamin D are common in patients with ileal pouches irrespective of pouch inflammation

Reena Khanna, Xianrui Wu and Bo Shen

in Journal of Crohn's and Colitis

Volume 7, issue 7, pages 525-533
Published in print August 2013 | ISSN: 1873-9946
Published online August 2013 | e-ISSN: 1876-4479 | DOI: https://dx.doi.org/10.1016/j.crohns.2012.08.006
Low levels of vitamin D are common in patients with ileal pouches irrespective of pouch inflammation

Show Summary Details

Preview

Abstract

Background: Vitamin D (25(OH) D3) levels in pouch patients are not well defined.

Aim: To evaluate the frequency and factors associated with low 25(OH) D3 levels in pouch patients with underlying inflammatory bowel disease (IBD).

Methods: A consecutive of 157 pouch patients was identified from our Pouchitis Registry. A sample of 155 ulcerative colitis (UC) patients without IPAA served as controls.

Results: The mean age of the cohort was 37.5 ± 14.2 years, with 86 (54.8%) being female. Low 25(OH)D3 levels (< 31 ng/mL) were detected in 69.4% of patients (N = 109). 34 (21.7%) of the 157 patients examined were 25(OH)D3 deficient (< 20 ng/mL). This was higher than the frequency of vitamin D insufficiency or deficiency in a sample of UC patients without IPAA. Between patients with and without normal 25(OH) D3 levels (> 31 ng/mL), no differences were identified in terms of demographic, pouch, and medication variables. A low hemoglobin level was found to be associated with low 25(OH) D3 levels in both univariate (p = 0.02) and multivariate analyses (odds ratio [OR] = 3.37; 95% confidence interval [CI]: 1.41–8.06; p = 0.01). Low levels of 25(OH)D3 was not related to markers of pouch inflammation, in particular there was no relation to pouchitis (OR = 1.20; 95% CI: 0.41–3.52; p = 0.74).

Conclusion: Low 25(OH)D3 level was common in this cohort, irrespective of inflammation of the pouch, possibly suggesting a strategy of routine testing in this population. Anemia was found to be associated with a low 25(OH)D3 level.

Keywords: Anemia;; Ileal pouch–anal anastomosis;; Inflammatory bowel disease;; Restorative proctocolectomy;; Vitamin D

Journal Article.  4338 words. 

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content. subscribe or login to access all content.