Journal Article

Outcomes after ileal pouch anal anastomosis in patients with primary sclerosing cholangitis

Michael Pavlides, Jon Cleland, Monira Rahman, Annabel Christian, Jennifer Doyle, Robert Gaunt, Simon Travis, Neil Mortensen and Roger Chapman

in Journal of Crohn's and Colitis

Volume 8, issue 7, pages 662-670
Published in print July 2014 | ISSN: 1873-9946
Published online July 2014 | e-ISSN: 1876-4479 | DOI: https://dx.doi.org/10.1016/j.crohns.2013.12.007
Outcomes after ileal pouch anal anastomosis in patients with primary sclerosing cholangitis☆

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Background and aims

Outcomes after ileal pouch anal anastomosis (IPAA) are not well established in patients with primary sclerosing cholangitis (PSC). We conducted a comprehensive outcomes assessment in these patients.

Methods

A retrospective case note review of complications in all PSC-IPAA (n = 21) and matched ulcerative colitis patients with IPAA (UC-IPAA; n = 79) after surgery in Oxford (1983–2012) was conducted, and functional outcomes (Öresland score) were evaluated (2012). Quality of life [Cleveland Global Quality of Life Questionnaire, Short Form-36 (SF-36)], and sexual function were also assessed (2012) including patients with PSC-associated UC without IPAA (PSC-UC; n = 19). Sub-group analysis of patients with large duct (ld) PSC-IPAA (n = 17) was also performed.

Keywords: Acute pouchitis; Pouch dysfunction; Quality of life; Sexual function

Journal Article.  5212 words.  Illustrated.

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