Journal Article

Plasma B-type natriuretic peptide concentration in β-thalassaemia patients

Athanasios Aessopos, Dimitrios Farmakis, Aikaterini Polonifi, Maria Tsironi, Christina Fragodimitri, Antonia Hatziliami, Markisia Karagiorga and Evanthia Diamanti-Kandarakis

in European Journal of Heart Failure

Published on behalf of European Society of Cardiology

Volume 9, issue 5, pages 537-541
Published in print May 2007 | ISSN: 1388-9842
Published online May 2007 | e-ISSN: 1879-0844 | DOI:
Plasma B-type natriuretic peptide concentration in β-thalassaemia patients

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Plasma B-type natriuretic peptide (BNP) concentration has significant diagnostic accuracy and prognostic value in various forms of heart disease. Whether BNP is also useful in the evaluation and management of thalassaemia heart disease remains to be determined.

Methods and results

Eighty three thalassaemia major patients; 8 with acutely decompensated heart failure (New York Heart Association [NYHA] class III or IV, group A), 25 with NYHA class II symptoms and impaired systolic left ventricular function (ejection fraction<55% or fractional shortening<30%, group B) and 50 with normal systolic function (group C), as well as 50 healthy controls, were studied. Assessment included history, physical examination, Doppler echocardiography and plasma BNP determination. Mean BNP levels were 431±219 pg/mL (range, 283–890 pg/mL) in group A, 158±31 pg/mL in group B, 176±54 pg/mL in group C and 43±24 pg/mL in controls. BNP levels were significantly higher in group A (p<0.001), but did not differ between groups B and C. Moreover, BNP was not correlated with left ventricular end-diastolic diameter, left ventricular mass, right ventricular diameter index, Doppler diastolic indexes (except in group C), the mean 2-year serum ferritin concentration or the peak serum ferritin concentration in any of the three patient groups.


A potential deficiency of BNP-related neurohormonal mechanisms may impair its clinical usefulness in thalassaemia major.

Keywords: Thalassaemia; Natriuretic peptides; BNP; Heart failure

Journal Article.  2968 words. 

Subjects: Cardiovascular Medicine

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