Journal Article

Identification of genetic markers for Mycobacterium pinnipedii through genome analysis

Fabiana Bigi, M. Carmen Garcia-Pelayo, Javier Nuñez-García, Andrea Peralta, Karina C. Caimi, Paul Golby, Jason Hinds, Angel Cataldi, Stephen V. Gordon and Maria I. Romano

in FEMS Microbiology Letters

Volume 248, issue 2, pages 147-152
Published in print July 2005 |
Published online January 2006 | e-ISSN: 1574-6968 | DOI: https://dx.doi.org/10.1016/j.femsle.2005.05.034

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Abstract

Tuberculosis in seals is caused by Mycobacterium pinnipedii, a member of the Mycobacterium tuberculosis complex. In this study, we evaluated the extent of genetic variability among Mycobacterium bovis and M. pinnipedii by microarray-based comparative genomics. We identified two deletions that are exclusive to M. pinnipedii: PiD1 that removes the orthologues of the M. tuberculosis genes Rv3530c and Rv3531c, and PiD2 that encompasses genes Rv1977 and Rv1978. Interestingly, a deletion overlapping the previously described RD2 region was identified in some isolates of Mycobacterium microti and further characterised.

Keywords: Mycobacterium pinnipedii; Mycobacterium bovis; Genomic; Deletion

Journal Article.  3005 words.  Illustrated.

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