Journal Article

C-Reactive Protein Mediates the Effect of Apolipoprotein E on Cytomegalovirus Infection

Allison E. Aiello, Hoang-Oanh T. Nguyen and Mary N. Haan

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 197, issue 1, pages 34-41
Published in print January 2008 | ISSN: 0022-1899
Published online January 2008 | e-ISSN: 1537-6613 | DOI: https://dx.doi.org/10.1086/524144
C-Reactive Protein Mediates the Effect of Apolipoprotein E on Cytomegalovirus Infection

More Like This

Show all results sharing these subjects:

  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

GO

Show Summary Details

Preview

Background. Although the apolipoprotein (APOE)-ε4 allele has been shown to determine the outcome of several infections, its relationship with cytomegalovirus (CMV) has not been explored. We examine whether APOE determines CMV and herpes simplex virus type 1 (HSV-1) antibody levels and assess whether C-reactive protein (CRP) mediates any observed relationships.

Methods. We conducted a cross-sectional analysis of a randomly selected subset (n = 1561/1789) of participants aged 60 -101 in the Sacramento Area Latino Study on Aging. Blood samples were tested for APOE genotype, CRP, and immunoglobulin G antibodies to CMV and HSV-1. Multivariate logistic regression was used to examine the association between ε4 and CMV and HSV antibody levels. We also assessed whether CRP mediates the effects of any observed associations between ε4 and viral antibody levels.

Results. CMV antibody and CRP levels varied significantly by APOE genotype. The association between CRP and CMV antibody was strengthened in the presence of ε4. In contrast, this effect was not observed in HSV-1. We found that APOE-ε4 carriers had significantly lower levels of CRP yet significantly higher levels of CMV antibodies, suggesting a mediating pathway.

Conclusions. APOE-ε4 carriers may experience immunological aberrations that lead to lower levels of CRP and correspondingly higher CMV antibody levels.

Journal Article.  4922 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content. subscribe or login to access all content.