Ion channel trafficking, like that of other heteromeric membrane proteins, proceeds in a number of stages, and in the case of voltage-dependent calcium channels (VDCCs) very little is known about any of these processes. Starting from the initial translation of subunit mRNA into protein, a number of distinct but interdependent processes must occur, including the translocation of transmembrane subunits into the membrane of the endoplasmic reticulum, post-translational modification and the folding of individual subunits, oligomerization and association with auxiliary subunits, and trafficking through the endoplasmic reticulum and trans-Golgi network. All these are likely to occur on overlapping timescales, and are not expected to be independent processes.
Keywords: VDCCs; ion channel trafficking; subunit mRNA; translation; oligomerization; translocation; transmembrane subunits
Chapter. 15094 words. Illustrated.
Full text: subscription required