This autobiography describes his family upbringing, his undergraduate and graduate medical education, his early clinical training and the beginnings of his neuroscience research career. The details of early neuropharmacological training with micro-iontophoresis, defining the effects of neurotransmitters such as acetylcholine, norepinephrine, dopamine and serotonin led to attempts to localize these transmitters circuits by histochemistry light microscopy and electron microscopy. Of special interest has been the neurons of the locus coeruleus, their unique second-messenger mediated synaptic actions and their ever growing behavioral repertoire. The later stages of his career involving societal responsibilities and the training of young scientists are described as are his major mentors Gordon Schopefle, Erminio Costa, Nino Salmoiraghi, Nicholas Giarman, Francis O. Schmitt and Daniel X. Freedman.
Keywords: micro-iontophoresis; neurotransmitters; acetylcholine; norepinephrine; serotonin; histochemistry; light microscopy; electron microscopy; Locus coeruleus; second-messenger
Chapter. 26092 words. Illustrated.
Full text: subscription required