Naomi E. Chayen, John R. Helliwell and Edward H. Snell

in Macromolecular Crystallization and Crystal Perfection

Published in print March 2010 | ISBN: 9780199213252
Published online May 2010 | e-ISBN: 9780191707575 | DOI:

Series: International Union of Crystallography Monographs on Crystallography


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The ‘hits’ or ‘leads’ found during the screening stage that point to conditions that may be conducive to crystallization, need to be optimized in order to attain high quality crystals. This chapter highlights a variety of optimization techniques that go beyond the mere fine‐tuning of the conditions of the screen. Such techniques involve the manipulation of the crystallization phase diagram, including practical ways of separating nucleation and growth.

Keywords: optimization of crystal growth; dilution; separation of nucleation and growth; phase diagrams; dynamic light scattering; seeding

Chapter.  3912 words.  Illustrated.

Subjects: Crystallography

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