Reference Entry

formins

John Lackie

in A Dictionary of Biomedicine

Published in print January 2010 | ISBN: 9780199549351
Published online January 2010 | e-ISBN: 9780191727948
formins

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A conserved protein family originally identified as alternatively spliced products of the ld (limb deformity) locus of the mouse, mutations in which disrupt pattern formation, cause limb deformities and renal aplasia. Formins are involved in regulating actin and microtubule networks, signalling to the nucleus and in embryonic development. A characteristic feature are the ...

Reference Entry.  86 words. 

Subjects: Clinical Medicine

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