Journal Article

Apolipoprotein C-III and High-Density Lipoprotein Subspecies Defined by Apolipoprotein C-III in Relation to Diabetes Risk

Sarah A. Aroner, Ming Yang, Junlong Li, Jeremy D. Furtado, Frank M. Sacks, Anne Tjønneland, Kim Overvad, Tianxi Cai and Majken K. Jensen

in American Journal of Epidemiology

Published on behalf of Society for Epidemiologic Research

Volume 186, issue 6, pages 736-744
Published in print September 2017 | ISSN: 0002-9262
Published online August 2017 | e-ISSN: 1476-6256 | DOI: https://dx.doi.org/10.1093/aje/kwx143
Apolipoprotein C-III and High-Density Lipoprotein Subspecies Defined by Apolipoprotein C-III in Relation to Diabetes Risk

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Abstract

Apolipoprotein C-III (apoC-III) is a potentially novel biomarker that may play an important role in the pathogenesis of diabetes, particularly when present on the surface of high-density lipoprotein (HDL). In a case-cohort study carried out among 434 incident diabetes cases occurring before 2007 and 3,101 noncases in the Danish Diet, Cancer, and Health Study, we examined associations of baseline (1993–1997) plasma concentrations of apoC-III and subspecies of HDL defined by the presence or absence of apoC-III with risk of diabetes using Cox regression. ApoC-III was strongly associated with risk of diabetes (for top quintile vs. bottom quintile, hazard ratio (HR) = 3.43, 95% confidence interval (CI): 1.75, 6.70; P-trend < 0.001). The cholesterol concentration of HDL (HDL cholesterol (HDL-C)) without apoC-III was inversely associated with risk of diabetes (HR = 0.48, 95% CI: 0.27, 0.85; P-trend = 0.002), more so than total HDL-C (HR = 0.60, 95% CI: 0.35, 1.03; P-trend = 0.04), whereas HDL-C with apoC-III was not associated (HR = 1.05, 95% CI: 0.50, 2.21; P-trend = 0.44) (for HDL-C with apoC-III vs. HDL-C without apoC-III, P-heterogeneity = 0.002). ApoC-III itself is a strong risk marker for diabetes, and its presence on HDL may impair the antidiabetogenic properties of HDL. ApoC-III has potential to be a therapeutic target for the prevention of diabetes.

Keywords: apolipoprotein; apolipoprotein C-III; biomarkers; diabetes; high-density lipoprotein

Journal Article.  5998 words.  Illustrated.

Subjects: Public Health and Epidemiology

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