Journal Article

LITTLE KEVIN: a program for the estimation of protein homology by analysing the amino acid compositions and sequences

J.P. Grillasca, D. Aubert, R. Planells, N. Domingo and H. Lafont

in Bioinformatics

Volume 12, issue 4, pages 347-351
Published in print August 1996 | ISSN: 1367-4803
Published online August 1996 | e-ISSN: 1460-2059 | DOI: https://dx.doi.org/10.1093/bioinformatics/12.4.347

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We present here a computational method based on the analysis of amino acid composition for performing comparisons between proteins. This user-friendly and reliable test is aimed at rapidly identifying, from data-base subsets, sequences—if necessary, partial sequences—which share similar amino acid compositions to the input composition (deduced from experimental results). Apparent molecular weight (as determined by SDS-PAGE) and artefactual modifications due to the experimental determination of the amino acid composition are taken into account to perform the comparison. This program thus constitutes a useful tool in searching for the probable identification of either nonsequenced proteins or peptides from hydrolysed proteins.

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Subjects: Bioinformatics and Computational Biology