Journal Article

Polyphenon E®, a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic PC3 by necroptosis

Federica Rizzi, Valeria Naponelli, Alessandro Silva, Alice Modernelli, Ileana Ramazzina, Martina Bonacini, Saverio Tardito, Rita Gatti, Jacopo Uggeri and Saverio Bettuzzi

in Carcinogenesis

Volume 35, issue 4, pages 828-839
Published in print April 2014 | ISSN: 0143-3334
Published online December 2013 | e-ISSN: 1460-2180 | DOI: https://dx.doi.org/10.1093/carcin/bgt481

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Polyphenon E®-induced ERS represents the key event leading to cell death in PCa secretory cells because of the extraordinary demand of protein posttranslational processing, which easily can exceed the capacity of these cells to assist protein folding.

Journal Article.  8414 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics