Journal Article

Modernizing Surveillance of Antituberculosis Drug Resistance: From Special Surveys to Routine Testing

Matteo Zignol, Wayne van Gemert, Dennis Falzon, Ernesto Jaramillo, Léopold Blanc and Mario Raviglione

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 52, issue 7, pages 901-906
Published in print April 2011 | ISSN: 1058-4838
Published online April 2011 | e-ISSN: 1537-6591 | DOI:

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Resistance to antituberculosis drugs has been documented since the 1940s, when the first medicines for tuberculosis were introduced. Since the initiation in 1994 of a global project to monitor the development of drug-resistant tuberculosis, nearly 60% of all countries in the world have implemented surveillance activities. In the past 15 years, special surveys have been the most common approach to investigate the frequency and patterns of drug-resistant tuberculosis. The major obstacle to the expansion of routine surveillance activities has been the lack of laboratory capacity needed to detect resistance. We are now in a new era for antituberculosis drug resistance surveillance due to the advent of new diagnostic tools and global commitment towards universal access to care for all patients with tuberculosis, including those with drug-resistant disease. Routine surveillance linked to patient care, which represents the best approach to monitor drug resistance, now has the possibility of becoming a reality even in resource-limited countries.

Journal Article.  3704 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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