Journal Article

The Evolution of Resistance to Cephalosporins

Faridah Moosdeen

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 24, issue 3, pages 487-493
Published in print March 1997 | ISSN: 1058-4838
Published online March 1997 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1093/clinids/24.3.487
The Evolution of Resistance to Cephalosporins

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The expression of resistance to cephalosporins is highly varied and due to various mechanisms. The greatest disadvantage of the cephalosporins is that they are inactivated by the array of β-lactamases produced by bacteria. The high levels of chromosomal enzymes produced by these organisms are a major cause of cephalosporin resistance. Plasmid-mediated β-lactamases (PMBLs) have also been implicated as causes of resistance, and other cephalosporinases have been described. Point mutations of specific amino acids of well-recognized PMBLs (e.g., TEM-1 and SHV-1) have also produced enzymes capable of attacking a wider spectrum of β-lactam agents. The availability of newer β-lactams may be conducive to the development of such β-lactamases, in which chromosomal and newer plasmid derivatives that may or may not contain the AmpC gene are selected. The occurrence of such enzymes is likely to continue to increase.

Journal Article.  0 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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