Journal Article

PGC-1β Down-Regulation Is Associated With Reduced ERRα Activity and MCAD Expression in Skeletal Muscle of Senescence-Accelerated Mice

Ricardo Rodríguez-Calvo, Mireia Jové, Teresa Coll, Antoni Camins, Rosa M. Sánchez, Marta Alegret, Manuel Merlos, Mercè Pallàs, Juan C. Laguna and Manuel Vázquez-Carrera

in The Journals of Gerontology: Series A

Published on behalf of The Gerontological Society of America

Volume 61, issue 8, pages 773-780
Published in print August 2006 | ISSN: 1079-5006
Published online August 2006 | e-ISSN: 1758-535X | DOI: https://dx.doi.org/10.1093/gerona/61.8.773
PGC-1β Down-Regulation Is Associated With Reduced ERRα Activity and MCAD Expression in Skeletal Muscle of Senescence-Accelerated Mice

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Mitochondrial dysfunction is involved in the development of aging. Here, we examined the effect of aging on the skeletal muscle expression of two isoforms of the transcriptional peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1 (PGC-1) in an experimental murine model of accelerated aging, the senescence-accelerated mouse (SAM). The senescence-accelerated prone mice (SAM-P8) showed no changes in PGC-1α, but a decrease in PGC-1β expression (52% reduction, p <.001) was observed compared to the senescence-accelerated resistant mice (SAM-R1). In agreement with the proposed role of PGC-1β as an estrogen-related receptor (ERR) protein ligand, the expression of the ERRα target gene medium-chain acyl-coenzyme A dehydrogenase was strongly suppressed (85%, p <.001) in SAM-P8. The decrease in the expression of medium-chain acyl-coenzyme A dehydrogenase was consistent with the reduction in ERRα DNA-binding activity of SAM-P8. These findings indicate that the age-mediated decrease in PGC-1β expression in SAM-P8 skeletal muscle affects the expression of genes involved in mitochondrial fatty acid oxidation.

Journal Article.  4858 words.  Illustrated.

Subjects: Geriatric Medicine ; Biological Sciences

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