Journal Article

Tissue renin-angiotensin systems and reproduction.

G P Vinson, E Saridogan, J R Puddefoot and O Djahanbakhch

in Human Reproduction

Published on behalf of European Society of Human Reproduction and Embryology

Volume 12, issue 4, pages 651-662
Published in print April 1997 | ISSN: 0268-1161
Published online April 1997 | e-ISSN: 1460-2350 | DOI:
Tissue renin-angiotensin systems and reproduction.

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The continued acquisition of information on the distribution of expression of components of the renin-angiotensin system shows that it has functions in the tissues that are quite unrelated to its systemic actions. In particular, both type 1 and type 2 angiotensin receptors are found in many tissues of the reproductive system of both sexes. In addition, the widespread occurrence of (pro)renin, angiotensin converting enzyme and angiotensinogen suggests that the generation of angiotensin II within the tissues occurs at sites close to its sites of action. The data suggest that angiotensin II operates as an important paracrine agent with profoundly significant roles in several functions of the reproductive system, and in fertility.

Journal Article.  0 words. 

Subjects: Reproductive Medicine

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