Journal Article

Contraceptive efficacy of daily administration of 0.5 mg mifepristone

Lena Marions, Sandor Viski, Kristina Gemzell Danielsson, Bela A. Resch, Marja-Liisa Swahn, Marc Bygdeman and László Kovâcs

in Human Reproduction

Published on behalf of European Society of Human Reproduction and Embryology

Volume 14, issue 11, pages 2788-2790
Published in print November 1999 | ISSN: 0268-1161
Published online November 1999 | e-ISSN: 1460-2350 | DOI: https://dx.doi.org/10.1093/humrep/14.11.2788
Contraceptive efficacy of daily administration of 0.5 mg mifepristone

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The antiprogestin mifepristone has shown potential to be used as a contraceptive. If 200 mg mifepristone is administered immediately after ovulation, the endometrium shows sufficient impairment of secretory development to prevent implantation. Low daily doses of mifepristone have been shown to reduce several of the local factors regarded as crucial for implantation in human endometrium. To find out if this regimen is sufficient to prevent pregnancy, 32 women were recruited for a study where 0.5 mg mifepristone was administered daily. A total of 141 cycles were studied. Five pregnancies occurred, which was significantly less than if no contraceptive method had been used. However, the dose chosen did not seem sufficient to act as a contraceptive although it is probably not possible to increase the dose without disturbing ovulation and bleeding pattern.

Keywords: antiprogestin; contraception; implantation; mifepristone

Journal Article.  2609 words.  Illustrated.

Subjects: Reproductive Medicine

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