Journal Article

Return of Widespread Chloroquine-Sensitive Plasmodium falciparum to Malawi

Anne E. P. Frosch, Miriam K. Laufer, Don P. Mathanga, Shannon Takala-Harrison, Jacek Skarbinski, Cassidy W. Claassen, Fraction K. Dzinjalamala and Christopher V. Plowe

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 210, issue 7, pages 1110-1114
Published in print October 2014 | ISSN: 0022-1899
Published online April 2014 | e-ISSN: 1537-6613 | DOI: https://dx.doi.org/10.1093/infdis/jiu216
Return of Widespread Chloroquine-Sensitive Plasmodium falciparum to Malawi

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Background. The return of chloroquine-sensitive Plasmodium falciparum to the limited area of Blantyre, Malawi, has been well demonstrated in several studies.

Methods. To characterize chloroquine susceptibility over a wide geographic area, infants and children aged 6–59 months were selected using 2-stage cluster sampling in 8 Malawian districts. Pyrosequencing of the pfcrt gene codon 76 region was performed for children with asexual parasitemia.

Results. Of 7145 children, 1150 had microscopic asexual parasitemia, and sequencing was performed in 685, of whom 1 had a chloroquine-resistant genotype.

Conclusions. Systematic countrywide sampling demonstrates that the chloroquine pfcrt genotype has reached near-fixation, raising the possibility of reintroducing chloroquine for malaria prevention and treatment.

Keywords: malaria; Plasmodium falciparum; chloroquine; resistance; PfCRT; Malawi; Africa

Journal Article.  2305 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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