Epidemiology and risk factors for calcium pyrophosphate deposition

Abhishek Abhishek and Michael Doherty

in Oxford Textbook of Osteoarthritis and Crystal Arthropathy

Third edition

Published on behalf of Oxford University Press

Published in print October 2016 | ISBN: 9780199668847
Published online November 2016 | e-ISBN: 9780191807176 | DOI:

Series: Oxford Textbooks in Rheumatology

Epidemiology and risk factors for calcium pyrophosphate deposition

Show Summary Details


Calcium pyrophosphate crystal deposition (CPPD) is rare in younger adults but becomes increasingly common over the age of 55 years, especially at the knee. Ageing and osteoarthritis (OA) are the main attributable risk factors. Hyperparathyroidism, hypomagnesaemia, haemochromatosis, and hypophosphatasia are other less common risk factors. Rare families with familial CPPD have been reported from many different parts of the world, and mainly present as young-onset polyarticular CPPD. Recent studies suggest that CPPD occurs as the result of a generalized constitutional predisposition and may also associate with low cortical bone mineral density. Previous meniscectomy, joint injury, and constitutional knee malalignment are local biomechanical risk factors specifically for knee chondrocalcinosis. Although associated with OA, current evidence suggests that CPPD does not associate with development or progression of OA.

Chapter.  3376 words. 

Subjects: Rheumatology

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content. subscribe or login to access all content.