Chapter

Transformed follicular lymphoma

Chern Siang Lee

in Challenging Concepts in Oncology

Published on behalf of Oxford University Press

Published in print April 2015 | ISBN: 9780199688883
Published online July 2015 | e-ISBN: 9780191768033 | DOI: https://dx.doi.org/10.1093/med/9780199688883.003.0015

Series: Challenging Concepts

Transformed follicular lymphoma

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Follicular lymphoma is the commonest subtype of indolent non-Hodgkin’s lymphoma (NHL), with a steady rise in incidence over the last 40 years. It has a long clinical course, characterized by a progressing and regressing pattern in response to treatment, and is usually considered incurable. There is no consensus on optimal therapy, but the management strategy incorporates consideration of tumour characteristics and patient-related factors. The quality and duration of response typically decline with repeated treatments. This is particularly in the event of histological transformation to a more aggressive subtype of NHL such as diffuse large B-cell lymphoma. This case study illustrates the clinical approach to lymphoma in general and discusses in detail the management paradigm for indolent and transformed NHL.

Chapter.  4823 words.  Illustrated.

Subjects: Radiation Oncology

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