Chapter

Soft tissue trauma and rhabdomyolysis

Paula Ferrada

in Trauma Intensive Care

Published on behalf of Oxford University Press

Published in print May 2013 | ISBN: 9780199777709
Published online September 2013 | e-ISBN: 9780199353057 | DOI: https://dx.doi.org/10.1093/med/9780199777709.003.0010

Series: Pittsburgh Critical Care Medicine

Soft tissue trauma and rhabdomyolysis

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Rhabdomyolysis is the breakdown of muscle fibers with leakage of intracellularcontents into the systemic circulation. The result of this extracellular rush of intracellular contents is multi-systemic. One of the devastating consequences ofthis disease is renal failure. This is due to decreased renal perfusion, cast formationwith tubular obstruction, and the direct toxic effects of myoglobin on therenal tubules. Trauma, particularly crush injury, is the most common predisposingfactor for this disease. Any patient with crush injury or/and a large amount of muscle compromisefrom soft tissue injury must be treated for rhabdomyolysis until provenotherwise.

Chapter.  1244 words. 

Subjects: Critical Care ; Trauma and Orthopaedic Surgery

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