Journal Article

Birth and Evolutionary History of a Human Minisatellite

Francisco Boán, Miguel G. Blanco, Javier Quinteiro, Susana Mouriño and Jaime Gómez-Márquez

in Molecular Biology and Evolution

Published on behalf of Society for Molecular Biology and Evolution

Volume 21, issue 2, pages 228-235
Published in print February 2004 | ISSN: 0737-4038
Published online February 2004 | e-ISSN: 1537-1719 | DOI: https://dx.doi.org/10.1093/molbev/msh007
Birth and Evolutionary History of a Human Minisatellite

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One of the most exciting challenges in human biology is the understanding of how our genome was constructed during evolution. Here we explore the evolutionary history of the low polymorphic human minisatellite MsH42 and its flanking sequences. We show that the evolutionary birth of MsH42 took place within an intron, early in primate lineage evolution, more than 40 MYA. Then, single base-pair changes and duplications/deletions of repeat blocks by mispairing were probably the main forces governing the generation of this minisatellite and its polymorphism throughout primate evolution. Moreover, we detected several phylogenetic footprints at both sides of MsH42. We believe that our findings will contribute to the understanding of low-variability minisatellite evolution.

Keywords: minisatellite evolution; phylogenetic footprint; primates; human minisatellite MsH42

Journal Article.  4585 words.  Illustrated.

Subjects: Evolutionary Biology ; Molecular and Cell Biology

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