Journal Article

Centromeres from telomeres? The centromeric region of the <i>Y</i> chromosome of <i>Drosophila melanogaster</i> contains a tandem array of telomeric HeT-A- and TART-related sequences

Marta Agudo, Ana Losada, José P. Abad, Sergio Pimpinelli, Pedro Ripoll and Alfredo Villasante

in Nucleic Acids Research

Volume 27, issue 16, pages 3318-3324
Published in print August 1999 | ISSN: 0305-1048
Published online August 1999 | e-ISSN: 1362-4962 | DOI: https://dx.doi.org/10.1093/nar/27.16.3318
Centromeres from telomeres? The centromeric region of the Y chromosome of Drosophila melanogaster contains a tandem array of telomeric HeT-A- and TART-related sequences

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Cytological and cytogenetic studies have previously defined the region needed for centromeric function in the Y chromosome of Drosophila melanogaster. We have identified a YAC clone that originated from this region. Molecular analysis of the YAC and genomic DNAs has allowed the description of a satellite DNA made of telomeric HeT-A- and TART-derived sequences and the construction of a long-range physical map of the heterochromatic region h18. Sequences within the YAC clone are conserved in the centromeric region of the sibling species Drosophila simulans. That telomere-derived DNA now forms part of the centromeric region of the Y chromosome could indicate a telomeric origin of this centromere. The existence of common determinants for the function of both centromeres and telomeres is discussed.

Journal Article.  4884 words.  Illustrated.

Subjects: Chemistry ; Biochemistry ; Bioinformatics and Computational Biology ; Genetics and Genomics ; Molecular and Cell Biology

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