Journal Article

Transcription of genes encoding trans‐acting factors required for rRNA maturation/ribosomal subunit assembly is coordinately regulated with ribosomal protein genes and involves Rap1 in Saccharomyces cerevisiae

Keita Miyoshi, Chiharu Shirai and Keiko Mizuta

in Nucleic Acids Research

Volume 31, issue 7, pages 1969-1973
Published in print April 2003 | ISSN: 0305-1048
Published online April 2003 | e-ISSN: 1362-4962 | DOI: https://dx.doi.org/10.1093/nar/gkg278

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We demonstrate that the genes encoding trans‐ acting factors essential for pre‐rRNA processing/ribosomal subunit assembly are responsive to various kinds of stresses such as heat shock, nitrogen deprivation and a secretory defect, in coordination with ribosomal protein genes in Saccharomyces cerevisiae. The rap1‐17 mutation, which produces the C‐terminally truncated protein of a transcriptional factor Rap1p, affects transcriptional repression of the trans‐acting factor genes due to a secretory defect as shown previously for both ribosomal protein and rRNA genes.

Journal Article.  3530 words.  Illustrated.

Subjects: Chemistry ; Biochemistry ; Bioinformatics and Computational Biology ; Genetics and Genomics ; Molecular and Cell Biology