Journal Article

OGEE: an online gene essentiality database

Wei-Hua Chen, Pablo Minguez, Martin J. Lercher and Peer Bork

in Nucleic Acids Research

Volume 40, issue D1, pages D901-D906
Published in print January 2012 | ISSN: 0305-1048
Published online November 2011 | e-ISSN: 1362-4962 | DOI: https://dx.doi.org/10.1093/nar/gkr986

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OGEE is an Online GEne Essentiality database. Its main purpose is to enhance our understanding of the essentiality of genes. This is achieved by collecting not only experimentally tested essential and non-essential genes, but also associated gene features such as expression profiles, duplication status, conservation across species, evolutionary origins and involvement in embryonic development. We focus on large-scale experiments and complement our data with text-mining results. Genes are organized into data sets according to their sources. Genes with variable essentiality status across data sets are tagged as conditionally essential, highlighting the complex interplay between gene functions and environments. Linked tools allow the user to compare gene essentiality among different gene groups, or compare features of essential genes to non-essential genes, and visualize the results. OGEE is freely available at http://ogeedb.embl.de.

Journal Article.  2699 words.  Illustrated.

Subjects: Chemistry ; Biochemistry ; Bioinformatics and Computational Biology ; Genetics and Genomics ; Molecular and Cell Biology