Journal Article

Three-dimensionally designed protein-responsive RNA devices for cell signaling regulation

Shunnichi Kashida, Tan Inoue and Hirohide Saito

in Nucleic Acids Research

Volume 40, issue 18, pages 9369-9378
Published in print October 2012 | ISSN: 0305-1048
Published online July 2012 | e-ISSN: 1362-4962 | DOI: https://dx.doi.org/10.1093/nar/gks668

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The three-dimensional (3D) structures of many biomacromolecules have been solved to reveal the functions of these molecules. However, these 3D structures have rarely been applied to constructing efficient molecular devices that function in living cells. Here, we demonstrate a 3D structure-based molecular design principle for constructing short hairpin RNA (shRNA)-mediated genetic information converters; these converters respond to specific proteins and trigger the desired gene expression by modulating the function of the RNA-processing enzyme Dicer. The inhibitory effect on Dicer cleavage...

Journal Article.  5440 words.  Illustrated.

Subjects: Chemistry ; Biochemistry ; Bioinformatics and Computational Biology ; Genetics and Genomics ; Molecular and Cell Biology

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