Journal Article

Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human

Benjamin Albert, Christine Colleran, Isabelle Léger-Silvestre, Axel B. Berger, Christophe Dez, Christophe Normand, Jorge Perez-Fernandez, Brian McStay and Olivier Gadal

in Nucleic Acids Research

Volume 41, issue 22, pages 10135-10149
Published in print December 2013 | ISSN: 0305-1048
Published online September 2013 | e-ISSN: 1362-4962 | DOI: https://dx.doi.org/10.1093/nar/gkt770

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Ribosome biogenesis is a major metabolic effort for growing cells. In Saccharomyces cerevisiae, Hmo1, an abundant high-mobility group box protein (HMGB) binds to the coding region of the RNA polymerase I transcribed ribosomal RNAs genes and the promoters of ∼70% of ribosomal protein genes. In this study, we have demonstrated the functional conservation of eukaryotic HMGB proteins involved in ribosomal DNA (rDNA) transcription. We have shown that when expressed in budding yeast, human UBF1 and a newly identified Sp-Hmo1 (Schizosaccharomyces pombe) localize to the nucleolus and suppress growth...

Journal Article.  8231 words.  Illustrated.

Subjects: Chemistry ; Biochemistry ; Bioinformatics and Computational Biology ; Genetics and Genomics ; Molecular and Cell Biology

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