Journal Article

Solution structure of the DNA complex with a quinacrine-netropsin hybrid molecule by NMR spectroscopy

Yukio Kubota, Seiji Tani and Rei Uchida

in Nucleic Acids Symposium Series

Volume 44, issue 1, pages 235-236
Published in print October 2000 | ISSN: 0261-3166
Published online October 2000 | e-ISSN: 1746-8272 | DOI: https://dx.doi.org/10.1093/nass/44.1.235
Solution structure of the DNA complex with a quinacrine-netropsin hybrid molecule by NMR spectroscopy

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The solution structures of 1:1 complexes of a quinacrine-netropsin hybrid molecule with the self-complementary DNA duplexes, d(CGCGAATTCGCG)2and d(CGAATTCG)2, have been studied by one-and two-dimensional 1H NMR spectroscopy. The NOE data indicate that the acridine ring of the hybrid intercalates into the 5′-GpA step and its netropsin moiety spans the minor groove of the central AATT region.

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Subjects: Chemistry ; Bioinformatics and Computational Biology ; Genetics and Genomics ; Molecular and Cell Biology

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