Journal Article

Effect of cationic comb-type copolymer on the B- Z transition of poly(dG-dC)·poly(dG-dC)

Naohiko Shimada, Arihiro Kano and Atsushi Maruyama

in Nucleic Acids Symposium Series

Volume 52, issue 1, pages 113-114
Published in print September 2008 | ISSN: 0261-3166
Published online September 2008 | e-ISSN: 1746-8272 | DOI: https://dx.doi.org/10.1093/nass/nrn058
Effect of cationic comb-type copolymer on the B- Z transition of poly(dG-dC)·poly(dG-dC)

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The structural transition of a double helical DNA from B-DNA to Z-DNA, B-Z transition, has been received growing attention because of its potential roles in biological systems and its applicability to nanobiotechnology. It was known that the B-Z transition is induced by cationic molecules. However, there are only a few reports describing cationic polymers as potential B-Z inducers. In this study, we demonstrated that cationic comb-type copolymer, poly(L-lysine)-graft-dextran, induced the B-Z transition in which distinct intermediate formation was involved. Furthermore, we suggested that the grafted-dextran plays an important role in the B-Z transition.

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Subjects: Chemistry ; Bioinformatics and Computational Biology ; Genetics and Genomics ; Molecular and Cell Biology

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