Journal Article

Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis

Shunsuke Yamada, Masatomo Taniguchi, Masanori Tokumoto, Kazuhiko Tsuruya and Mitsuo Iida

in Clinical Kidney Journal

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 2, issue 2, pages 155-157
Published in print April 2009 | ISSN: 1753-0784
Published online February 2009 | e-ISSN: 1753-0792 | DOI: https://dx.doi.org/10.1093/ndtplus/sfp010

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A 46-year-old woman under 6-year haemodialysis was admitted for uncontrollable hip pain. An X-ray film revealed calcified mass around the ‘left femur head’, which was diagnosed as calcium deposition by percutaneous biopsy. Calcinotic tissues were removed surgically, and the resected specimen revealed tumoral calcinosis caused by low bone turnover. A complete resolution of calcinotic lesions around the ‘left knee’ occurred 6 months after treatment modification. Immunohistochemistry showed recruitment of multi-nucleated giant cells positive for CD68, tartrate resistant acidic phosphatase and calcitonin receptor, indicative of osteoclast-like features. We propose the involvement of osteoclast-like cells in active resorption of tumoral calcinosis.

Keywords: calcitonin receptor; multi-nucleated giant cell; osteoclast; tumoral calcinosis

Journal Article.  1349 words.  Illustrated.

Subjects: Nephrology

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