Journal Article

Adult-onset Still's disease associated with collapsing glomerulopathy

Nishkantha Arulkumaran, Pablo Reitbock, Kirsty Halliday, James Onwubalili, Dakshina Jayasena and Peter J. Dupont

in Clinical Kidney Journal

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 3, issue 1, pages 54-56
Published in print February 2010 | ISSN: 1753-0784
Published online August 2009 | e-ISSN: 1753-0792 | DOI: https://dx.doi.org/10.1093/ndtplus/sfp114

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A young woman of African descent presented with fevers, arthralgia, lymphadenopathy and a skin rash. Modest proteinuria was also noted. The clinical picture suggested an acute HIV sero-conversion illness, and a renal biopsy showed a collapsing glomerulopathy compatible with that diagnosis. However, HIV serology proved persistently negative and a diagnosis of Adult Still's disease was subsequently made (by Yamaguchi criteria). Following steroid treatment, the patient's fever abated and her inflammatory markers returned to normal. Collapsing glomerulopathy is a rare but important complication of Adult Still's disease. Immunosuppressive treatment may be effective in improving renal outcome.

Keywords: Adult Still’s disease; collapsing glomerulopathy

Journal Article.  1251 words.  Illustrated.

Subjects: Nephrology

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