Journal Article

Hyperpigmented cutaneous lesions that flare-up with scratching: Darier's sign

Lyda B. Cuervo-Pardo, Alexei Gonzalez-Estrada, Sory J. Ruiz and Lily C. Pien

in Oxford Medical Case Reports

Volume 2015, issue 2, pages 188-190

Published online February 2015 | e-ISSN: 2053-8855 | DOI:

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We present the case of a 40-year-old male with a past medical history of urticaria pigmentosa (UP) who presented for consultation to the Allergy clinic for an opinion of systemic mastocytosis. Previous workups included elevated serum tryptase level, UP on skin biopsy and an increased number of CD117-positive/CD25-positive mast cells on bone marrow biopsy. This case emphasizes the importance of physical findings such as Darier's sign in patients with hyperpigmented lesions, which virtually supports the diagnosis UP, raises the suspicion for systemic mastocytosis and guides further diagnostic evaluation. This case also outlines the management of systemic mastocytosis.

Journal Article.  1095 words.  Illustrated.

Subjects: Medicine and Health ; Allergy

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