Journal Article

A New Low Density Lipoprotein Receptor Related Protein, LRP5, Is Expressed in Hepatocytes and Adrenal Cortex, and Recognizes Apolipoprotein E

Dong-Ho Kim, Yousuke Inagaki, Takashi Suzuki, Ryoichi X. Ioka, Shiroh Z. Yoshioka, Kenta Magoori, Man-Jong Kang, Yuko Cho, Akira Z. Nakano, Qiong Liu, Takahiro Fujino, Hiroyuki Suzuki, Hironobu Sasano and Tokuo T. Yamamoto

in The Journal of Biochemistry

Published on behalf of The Japanese Biochemical Society

Volume 124, issue 6, pages 1072-1076
Published in print December 1998 | ISSN: 0021-924X
Published online December 1998 | e-ISSN: 1756-2651 | DOI:

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The isolation and characterization of rabbit and human cDNAs revealed a new low density lipoprotein receptor (LDLR)-related protein (LRP) designated as LRP5. Human LRP5 cDNA encodes a 1,616-amino acid type I membrane-like protein with three ligand binding repeats in its extracellular region. LDLR-deficient cells transduced by recombinant adenovirus containing human LRP5 exhibited increased binding of apolipoprotein E (apoE)-enriched β-migrating very low density lipoprotein. Northern blotting and in situ hybridization revealed a high level of LRP5 expression in hepatocytes and the adrenal gland cortex. In LDLR-deficient Watanabe heritable hyperlipidemic rabbits, LRP5 mRNA was increased in the liver and accumulated in cholesterol-laden foam cells of atherosclerotic lesions.

Keywords: apoE; LDL receptor family; LDL receptor-related protein; lipoprotein

Journal Article.  0 words. 

Subjects: Biochemistry