Journal Article

The enigma of pulmonary hypertension after splenectomy—does the megakaryocyte provide a clue?

J. Thachil

in QJM: An International Journal of Medicine

Published on behalf of Association of Physicians of Great Britain and Ireland

Volume 102, issue 10, pages 743-745
Published in print October 2009 | ISSN: 1460-2725
Published online July 2009 | e-ISSN: 1460-2393 | DOI: https://dx.doi.org/10.1093/qjmed/hcp092
The enigma of pulmonary hypertension after splenectomy—does the megakaryocyte provide a clue?

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Pulmonary hypertension is a common and debilitating condition which is increasingly being recognized in haematological patients. This is particularly so in haemolytic diseases like thalassaemia and myeloproliferative conditions like idiopathic myelofibrosis. Recently, splenectomy, which may be required for some of these conditions, have been linked to this complication although the exact pathophysiology is still not established. The manuscript explains the role of the less recognized ‘lung megakaryocytes’ in the development of this complication.

Journal Article.  1451 words. 

Subjects: Medicine and Health

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