Journal Article

Microcrystals as DAMPs and their role in joint inflammation

Nathalie Busso and Alexander So

in Rheumatology

Volume 51, issue 7, pages 1154-1160
Published in print July 2012 | ISSN: 1462-0324
Published online February 2012 | e-ISSN: 1462-0332 | DOI: https://dx.doi.org/10.1093/rheumatology/ker524
Microcrystals as DAMPs and their role in joint inflammation

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Microcrystals associated with joint diseases, namely monosodium urate, calcium pyrophosphate and basic calcium phosphate, can be considered as ‘danger signals’ to the innate immune system and provoke inflammation through inflammasome-dependent as well as inflammasome-independent pathways. Direct crystal membrane interactions can also lead to cell activation. The result is the generation of IL-1β and other pro-inflammatory cytokines. The primacy of IL-1β in the case of gouty inflammation has been demonstrated by the efficacy of IL-1 inhibitors in clinical studies. These findings may be relevant to other diseases where crystal formation is found, such as OA and atherosclerosis.

Keywords: crystal arthropathies; inflammation; cytokines; animal models; physiology

Journal Article.  3718 words.  Illustrated.

Subjects: Rheumatology

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