Journal Article

0630 Clinical Symptoms of Our Narcoleptic Patients

N Pető and Z Szakacs

in SLEEP

Published on behalf of American Academy of Sleep Medicine

Volume 41, issue suppl_1, pages A234-A234
ISSN: 0161-8105
Published online April 2018 | e-ISSN: 1550-9109 | DOI: https://dx.doi.org/10.1093/sleep/zsy061.629

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  • Neurology
  • Sleep Medicine
  • Clinical Neuroscience
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Abstract

Introduction

At narcoleptic patients, a clinical,,tetrade” of characteristic symptoms can be found: excessive daytime sleepiness (EDS), cataplexy, sleep paralysis and hypnagog hallucinations. Fragmented sleep, amnestic episodes, automatic behaviour, headaches, weight gain also occur. The four main symptoms can rarely be observed together, which makes the diagnosis difficult. The aim of this study was to evaluate the the proportion of the symptoms of the clinical tetrade at our narcoleptic patients.

Methods

We used the data of the patients presented in our Sleep Centre from 2006 to 2016 with the symptom of excessive daytime sleepiness. We evaluated the daytime sleepiness with the Epworth Scale. PSG and MSLT were performed. The diagnosis was based on clinical findings, average sleep latency value and sleep onset REM periods measured by MSLT and the exclusion of other disorders causing EDS. We evaluated the distribution of the subjects according to age, final diagnosis and the clinical manifestation of narcolepsy, plus we observed the distribution of the main symptoms of the,,tetrade”.

Results

128 patients (age of 17–79) presented with the suspition of narcolepsy. 77 (30 men, 47 women) were proven to be narcoleptic. According to clinical manifestation, narcolepsy- cataplexy (N/C) occured at 63.6%, narcolepsy without cataplexy (N) at 32.5%, symptomatic narcolepsy (sN) at 3.9% of the subjects. On evaluation of the main symptoms, we found hypersomnia at 100%, cataplexy at 67.5%, sleep paralysis at 42.9% and hypnagog hallucinations at 33.8% of the narcoleptic patients. Every symptom of the classic tetrade could be observed at 20% of the cases. Age and the result of the MSLT examinations did not correlate with the number of the symptoms.

Conclusion

On examination of our narcoleptic patients, we found hypersomnia at every subject. The frequency of cataplexy, sleep paralysis and hypnagog hallutination in the evaluated sample correlated with the relevant literature data.

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Subjects: Neurology ; Sleep Medicine ; Clinical Neuroscience ; Neuroscience

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